ID   TX18A_CYRSC             Reviewed;         115 AA.
AC   B3FIN4; B3FIN5;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=U7-theraphotoxin-Hs1a;
DE            Short=U7-TRTX-Hs1a;
DE   AltName: Full=HWTX-XVIIIa1;
DE   AltName: Full=HWTX-XVIIIa2;
DE   Flags: Precursor;
OS   Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Cyriopagopus.
OX   NCBI_TaxID=29017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=18482741; DOI=10.1016/j.toxicon.2008.03.024;
RA   Jiang L., Peng L., Chen J., Zhang Y., Xiong X., Liang S.;
RT   "Molecular diversification based on analysis of expressed sequence tags
RT   from the venom glands of the Chinese bird spider Ornithoctonus huwena.";
RL   Toxicon 51:1479-1489(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18482741}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=HWTX-XVIIIa1;
CC         IsoId=B3FIN4-1; Sequence=Displayed;
CC       Name=2; Synonyms=HWTX-XVIIIa2, Truncated;
CC         IsoId=B3FIN4-2; Sequence=VSP_040197;
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:18482741}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
CC   -!- MISCELLANEOUS: [Isoform 2]: It is unsure whether this isoform is
CC       produced by alternative splicing or another event. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 25 family. F7 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; EU195228; ABY77681.1; -; mRNA.
DR   EMBL; EU195229; ABY77682.1; -; mRNA.
DR   AlphaFoldDB; B3FIN4; -.
DR   ArachnoServer; AS000584; U7-theraphotoxin-Hs1a.
DR   ArachnoServer; AS000540; U7-theraphotoxin-Hs1b.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Alternative splicing; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..51
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000401915"
FT   CHAIN           52..115
FT                   /note="U7-theraphotoxin-Hs1a"
FT                   /id="PRO_0000401916"
FT   VAR_SEQ         78..115
FT                   /note="YVAGVEKKSCKSKTSDNGFLNIIGQAANAVQNAASLCV -> T (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:18482741"
FT                   /id="VSP_040197"
SQ   SEQUENCE   115 AA;  12036 MW;  A6B71A06D6C0B743 CRC64;
     MKLSLIIIAT SLVIAVVAFP SKDSAATDFD KTESLENVEE RVETALDERP RACSKNPGES
     CTNNCECCGA TVVCASVYVA GVEKKSCKSK TSDNGFLNII GQAANAVQNA ASLCV