ID   TX18A_MANRB             Reviewed;          87 AA.
AC   A0A6G9KJM3;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   12-AUG-2020, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=U18-myrmicitoxin-Mri1a {ECO:0000303|PubMed:32182430};
DE            Short=U18-MYRTX-Mri1a {ECO:0000303|PubMed:32182430};
DE   Flags: Precursor;
OS   Manica rubida (European giant red ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Manica.
OX   NCBI_TaxID=219785 {ECO:0000312|EMBL:QIQ51456.1};
RN   [1] {ECO:0000312|EMBL:QIQ51456.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 33-50, FUNCTION,
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom gland {ECO:0000312|EMBL:QIQ51456.1};
RX   PubMed=32182430; DOI=10.1021/acs.jproteome.0c00048;
RA   Touchard A., Aili S.R., Tene N., Barasse V., Klopp C., Dejean A.,
RA   Kini R.M., Mrinalini X., Coquet L., Jouenne T., Lefranc B., Leprince J.,
RA   Escoubas P., Nicholson G.M., Treilhou M., Bonnafe E.;
RT   "Venom Peptide Repertoire of the European Myrmicine Ant Manica rubida:
RT   Identification of Insecticidal Toxins.";
RL   J. Proteome Res. 19:1800-1811(2020).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32182430}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:32182430}.
CC   -!- PTM: O-glycosylated. {ECO:0000269|PubMed:32182430}.
CC   -!- MASS SPECTROMETRY: Mass=6223.7; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:32182430};
CC   -!- SIMILARITY: Belongs to the EGF domain peptide family. {ECO:0000305}.
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DR   EMBL; MN765046; QIQ51456.1; -; mRNA.
DR   AlphaFoldDB; A0A6G9KJM3; -.
DR   SMR; A0A6G9KJM3; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:InterPro.
DR   GO; GO:0048018; F:receptor ligand activity; IEA:InterPro.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR043403; Gurken/Spitz.
DR   PANTHER; PTHR12332; PTHR12332; 1.
DR   Pfam; PF00008; EGF; 1.
DR   SMART; SM00181; EGF; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; EGF-like domain; Glycoprotein;
KW   Secreted; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         33..87
FT                   /note="U18-myrmicitoxin-Mri1a"
FT                   /evidence="ECO:0000269|PubMed:32182430"
FT                   /id="PRO_0000453058"
FT   DOMAIN          33..77
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        37..52
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        46..65
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        67..76
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   87 AA;  9810 MW;  7107DB44E6DC9E0A CRC64;
     MKNNYNRINT FIVYLMVTFS LISIISITEC TPNHDPCPPQ YAEALCLNGG TCFSVTIMGS
     DNYNCICAPG FRGWRCQEKD LDHPVNQ