TX18A_ODOMO
ID TX18A_ODOMO Reviewed; 61 AA.
AC A0A348G6J0;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 07-NOV-2018, sequence version 1.
DT 25-MAY-2022, entry version 11.
DE RecName: Full=U-poneritoxin(01)-Om5b {ECO:0000250|UniProtKB:A0A348G5W2};
DE Short=U-PONTX(01)-Om5b {ECO:0000250|UniProtKB:A0A348G5W2};
DE AltName: Full=Pilosulin-like peptide 8 {ECO:0000312|EMBL:BBF98063.1};
DE Short=PLP8 {ECO:0000250|UniProtKB:A0A348G6I7};
DE AltName: Full=Poneratoxin {ECO:0000305};
DE Flags: Precursor;
OS Odontomachus monticola (Trap-jaw ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Odontomachus.
OX NCBI_TaxID=613454;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=29027956; DOI=10.3390/toxins9100323;
RA Kazuma K., Masuko K., Konno K., Inagaki H.;
RT "Combined venom gland transcriptomic and venom peptidomic analysis of the
RT predatory ant Odontomachus monticola.";
RL Toxins 9:323-323(2017).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=30658410; DOI=10.3390/toxins11010050;
RA Tani N., Kazuma K., Ohtsuka Y., Shigeri Y., Masuko K., Konno K.,
RA Inagaki H.;
RT "Mass spectrometry analysis and biological characterization of the
RT predatory ant Odontomachus monticola venom and venom sac components.";
RL Toxins 11:0-0(2019).
CC -!- FUNCTION: Acidic peptide with potent hemolytic activities. It also
CC shows low antimicrobial activities against E.coli (MIC=50uM), as well
CC as histamine-releasing activity (28.3% at 10 uM). Does not have
CC activity against S.aureus, and S.cerevisiae.
CC {ECO:0000250|UniProtKB:A0A348G5W1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29027956}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:29027956}.
CC -!- PTM: Truncated sequences of this peptide have also been found in the
CC venom. It is possible they have been cleaved in the venom.
CC {ECO:0000305|PubMed:30658410}.
CC -!- SIMILARITY: Belongs to the formicidae venom precursor-01 superfamily.
CC {ECO:0000305}.
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DR EMBL; LC416797; BBF98063.1; -; mRNA.
DR AlphaFoldDB; A0A348G6J0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Amidation; Antimicrobial; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..41
FT /evidence="ECO:0000250|UniProtKB:A0A348G5W1"
FT /id="PRO_0000447081"
FT PEPTIDE 42..59
FT /note="U-poneritoxin(01)-Om5b"
FT /evidence="ECO:0000269|PubMed:30658410"
FT /id="PRO_5016831533"
FT MOD_RES 59
FT /note="Glutamine amide"
FT /evidence="ECO:0000250|UniProtKB:A0A348G5W1"
SQ SEQUENCE 61 AA; 6233 MW; 3BE32907E7E03E45 CRC64;
MKLSALSLAF AIILMMTIMY TKADADASAD AEADADAEAE AFWGALLAAA IPAITSAIQG
K