TX18_PHORI
ID TX18_PHORI Reviewed; 54 AA.
AC P83903;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=U1-ctenitoxin-Pr1a;
DE Short=U1-CNTX-Pr1a;
DE AltName: Full=Neurotoxin PRTx18C2;
DE Flags: Fragment;
OS Phoneutria reidyi (Brazilian Amazonian armed spider) (Ctenus reidyi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Phoneutria.
OX NCBI_TaxID=272752 {ECO:0000305};
RN [1]
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP SPECTROMETRY.
RC TISSUE=Venom;
RX PubMed=16278100; DOI=10.1016/j.cbpc.2005.09.010;
RA Richardson M., Pimenta A.M., Bemquerer M.P., Santoro M.M., Beirao P.S.,
RA Lima M.E., Figueiredo S.G., Bloch C. Jr., Vasconcelos E.A., Campos F.A.,
RA Gomes P.C., Cordeiro M.N.;
RT "Comparison of the partial proteomes of the venoms of Brazilian spiders of
RT the genus Phoneutria.";
RL Comp. Biochem. Physiol. 142:173-187(2006).
RN [2] {ECO:0000305}
RP FUNCTION.
RA Richardson M., Pimenta A.M.C., Bemquerer M.P., Santoro M.M.,
RA Figueiredo S.G., Cordeiro M.N.;
RT "New neurotoxin PRTx18C2 from venom of Brazilian Amazonian armed spider
RT Phoneutria reidyi.";
RL Submitted (APR-2004) to UniProtKB.
CC -!- FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium
CC channels (Cav). Causes rapid general flaccid paralysis followed by
CC death in 10-30 minutes when injected in mice at dose levels of 5 ug per
CC mouse. {ECO:0000269|Ref.2}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16278100,
CC ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000269|PubMed:16278100, ECO:0000305}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=8248.9; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:16278100, ECO:0000305};
CC -!- SIMILARITY: Belongs to the neurotoxin 04 (omega-agtx) family. 03 (type
CC II/III omega-agtx) subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P83903; -.
DR ArachnoServer; AS000216; U1-ctenitoxin-Pr1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR005853; Omega-agatoxin_II/III_CS.
DR InterPro; IPR013605; Toxin_34.
DR Pfam; PF08396; Toxin_34; 1.
DR PROSITE; PS60023; OMEGA_AGA_II_III; 1.
PE 1: Evidence at protein level;
KW Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Toxin;
KW Voltage-gated calcium channel impairing toxin.
FT CHAIN 1..>54
FT /note="U1-ctenitoxin-Pr1a"
FT /id="PRO_0000087614"
FT DISULFID 2..19
FT /evidence="ECO:0000305"
FT DISULFID 9..25
FT /evidence="ECO:0000305"
FT DISULFID 16..51
FT /evidence="ECO:0000305"
FT DISULFID 18..39
FT /evidence="ECO:0000305"
FT DISULFID 27..37
FT /evidence="ECO:0000305"
FT NON_TER 54
FT /evidence="ECO:0000305"
SQ SEQUENCE 54 AA; 5847 MW; 9705EB2D8BD85344 CRC64;
SCINHGDACD GYKDDCQCCR RNGFCSCSGI FGYKWNCICD VGTTATSYGI CMAK
