ID   C5I7_DERAN              Reviewed;          99 AA.
AC   A0A146B5A4;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   08-JUN-2016, sequence version 1.
DT   03-AUG-2022, entry version 4.
DE   RecName: Full=Complement inhibitor RaCI7 {ECO:0000303|PubMed:27018802};
DE   Flags: Precursor;
OS   Dermacentor andersoni (Rocky mountain wood tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae; Dermacentor.
OX   NCBI_TaxID=34620;
RN   [1] {ECO:0000312|EMBL:DAA64997.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Salivary gland;
RX   PubMed=27018802; DOI=10.1038/nsmb.3196;
RA   Jore M.M., Johnson S., Sheppard D., Barber N.M., Li Y.I., Nunn M.A.,
RA   Elmlund H., Lea S.M.;
RT   "Structural basis for therapeutic inhibition of complement C5.";
RL   Nat. Struct. Mol. Biol. 23:378-386(2016).
CC   -!- FUNCTION: Complement inhibitor (PubMed:27018802). Prevents complement-
CC       mediated C5 activation by binding to C5 (By similarity). Binds C5 at a
CC       different binding site than the other tick complement inbibitors OmCI
CC       and CirpT1, and the drug eculizumab (By similarity).
CC       {ECO:0000250|UniProtKB:A0A146B485, ECO:0000269|PubMed:27018802}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:27018802}.
CC   -!- TISSUE SPECIFICITY: Expressed by salivary glands.
CC       {ECO:0000305|PubMed:27018802}.
CC   -!- SIMILARITY: Belongs to the RaCI family. {ECO:0000305}.
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DR   EMBL; BK009408; DAA64997.1; -; mRNA.
DR   EMBL; EG363717; -; NOT_ANNOTATED_CDS; mRNA.
PE   3: Inferred from homology;
KW   Complement system impairing toxin; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..99
FT                   /note="Complement inhibitor RaCI7"
FT                   /id="PRO_5007523342"
FT   DISULFID        37..61
FT                   /evidence="ECO:0000250|UniProtKB:A0A146B485"
FT   DISULFID        42..63
FT                   /evidence="ECO:0000250|UniProtKB:A0A146B485"
FT   DISULFID        57..78
FT                   /evidence="ECO:0000250|UniProtKB:A0A146B485"
SQ   SEQUENCE   99 AA;  10281 MW;  B28034FA3BAC433A CRC64;
     MAALNGLVLL LLTISAMFIS ECYSSGESQS IQRKGQCEEV TCHRTLNHLG VAVTSGCPSG
     CLCVISAPDS AVNVNGTCYQ LMGSTSTTTS STPSSEDQE