ID   TX1A_MYRBA              Reviewed;          74 AA.
AC   Q68Y23;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=M-myrmeciitoxin-Mb1a {ECO:0000305};
DE            Short=M-MIITX-Mb1a {ECO:0000305};
DE   AltName: Full=Pilosulin-3 {ECO:0000303|PubMed:15246874};
DE   Flags: Precursor;
OS   Myrmecia banksi (Jack jumper ant) (Australian jumper ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmeciinae; Myrmeciini; Myrmecia.
OX   NCBI_TaxID=36171;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SYNTHESIS OF 51-73.
RC   TISSUE=Venom gland;
RX   PubMed=15246874; DOI=10.1016/j.abb.2004.05.013;
RA   Inagaki H., Akagi M., Imai H.T., Taylor R.W., Kubo T.;
RT   "Molecular cloning and biological characterization of novel antimicrobial
RT   peptides, pilosulin 3 and pilosulin 4, from a species of the Australian ant
RT   genus Myrmecia.";
RL   Arch. Biochem. Biophys. 428:170-178(2004).
CC   -!- FUNCTION: Shows moderate activity against E.coli and S.aureus (MIC<25
CC       uM), slight activity against B.subtilis (MIC<50 uM), and no activity
CC       against L.garvieae, P.aeruginosa, C.albicans, and S.cerevisiae. Has no
CC       hemolytic nor cytolytic activity. Causes an IgE-independent histamine
CC       release. {ECO:0000269|PubMed:15246874}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:15246874}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:15246874}.
CC   -!- SIMILARITY: Belongs to the formicidae venom precursor-01 superfamily.
CC       Ant pilosulin family. {ECO:0000305}.
CC   -!- CAUTION: M.banksi is a member of the M.pilosula complex, but is clearly
CC       distinct from M.pilosula species. {ECO:0000305}.
CC   -!- CAUTION: The name pilosulin-3 has also been attributed by Davies et
CC       al., 2004 to an heterodimer from M.pilosula. {ECO:0000305}.
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DR   EMBL; AB128064; BAD36779.1; -; mRNA.
DR   AlphaFoldDB; Q68Y23; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Amidation; Antibiotic; Antimicrobial; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..50
FT                   /evidence="ECO:0000305|PubMed:15246874"
FT                   /id="PRO_0000035166"
FT   PEPTIDE         51..73
FT                   /note="M-myrmeciitoxin-Mb1a"
FT                   /evidence="ECO:0000305|PubMed:15246874"
FT                   /id="PRO_0000035167"
FT   MOD_RES         73
FT                   /note="Glutamine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P0C023"
SQ   SEQUENCE   74 AA;  7585 MW;  95E14DB3C7054086 CRC64;
     MKLSCLLLTL AIIVVLTIVH APNVEAKALA DPESDAVGFA DAVGEADPNA IIGLVSKGTC
     VLVKTVCKKV LKQG