TX1A_MYRRB
ID TX1A_MYRRB Reviewed; 10 AA.
AC P0DSL0;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 08-MAY-2019, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=U1-myrmicitoxin-Mr1a {ECO:0000305};
DE Short=U1-MYRTX-Mr1a {ECO:0000305};
DE AltName: Full=U-myrmicitoxin-MRArub1 {ECO:0000303|PubMed:30717163};
DE Short=U-MYRTX-MRArub1 {ECO:0000303|PubMed:30717163};
OS Myrmica rubra (European fire ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Myrmica.
OX NCBI_TaxID=106198;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AMIDATION AT ALA-10, AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=30717163; DOI=10.3390/insects10020042;
RA Heep J., Klaus A., Kessel T., Seip M., Vilcinskas A., Skaljac M.;
RT "Proteomic analysis of the venom from the ruby ant Myrmica rubra and the
RT isolation of a novel insecticidal decapeptide.";
RL Insects 10:0-0(2019).
RN [2]
RP FUNCTION.
RX PubMed=31557881; DOI=10.3390/toxins11100562;
RA Heep J., Skaljac M., Grotmann J., Kessel T., Seip M., Schmidtberg H.,
RA Vilcinskas A.;
RT "Identification and Functional Characterization of a Novel Insecticidal
RT Decapeptide from the Myrmicine Ant Manica rubida.";
RL Toxins 11:0-0(2019).
CC -!- FUNCTION: Insecticidal toxin that reduces the survival of aphids
CC (A.pisum) (PubMed:30717163, PubMed:31557881). In addition, it increases
CC the sensitivity of the aphids to two commonly used chemical
CC insecticides (imidacloprid and methomyl) (PubMed:30717163). Does not
CC display any antibacterial or antifungal activity (PubMed:31557881).
CC {ECO:0000269|PubMed:30717163, ECO:0000269|PubMed:31557881}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30717163}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:30717163}.
CC -!- MASS SPECTROMETRY: Mass=1097.656; Method=Electrospray;
CC Note=Monoisotopic mass.; Evidence={ECO:0000269|PubMed:30717163};
CC -!- MISCELLANEOUS: This peptide does not show antimicrobial activity
CC (PubMed:30717163). {ECO:0000269|PubMed:30717163}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IDA:UniProtKB.
DR GO; GO:0035738; P:envenomation resulting in modulation of process in another organism; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW Amidation; Antimicrobial; Direct protein sequencing; Secreted; Toxin.
FT PEPTIDE 1..10
FT /note="U1-myrmicitoxin-Mr1a"
FT /evidence="ECO:0000269|PubMed:30717163"
FT /id="PRO_0000447104"
FT MOD_RES 10
FT /note="Alanine amide"
FT /evidence="ECO:0000269|PubMed:30717163"
SQ SEQUENCE 10 AA; 1098 MW; 39D918BB17272327 CRC64;
IDPKLLESLA
