ID   C5IT3_RHISA             Reviewed;         111 AA.
AC   P0DQV2;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=Complement inhibitor CirpT3 {ECO:0000303|PubMed:31871188};
DE   Flags: Precursor;
OS   Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae;
OC   Rhipicephalus; Rhipicephalus.
OX   NCBI_TaxID=34632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=20650005; DOI=10.1186/1471-2164-11-450;
RA   Anatriello E., Ribeiro J.M., de Miranda-Santos I.K., Brandao L.G.,
RA   Anderson J.M., Valenzuela J.G., Maruyama S.R., Silva J.S., Ferreira B.R.;
RT   "An insight into the sialotranscriptome of the brown dog tick,
RT   Rhipicephalus sanguineus.";
RL   BMC Genomics 11:450-450(2010).
RN   [2]
RP   FUNCTION, AND RECOMBINANT EXPRESSION.
RC   TISSUE=Salivary gland;
RX   PubMed=31871188; DOI=10.1073/pnas.1909973116;
RA   Reichhardt M.P., Johnson S., Tang T., Morgan T., Tebeka N., Popitsch N.,
RA   Deme J.C., Jore M.M., Lea S.M.;
RT   "An inhibitor of complement C5 provides structural insights into
RT   activation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 117:362-370(2020).
CC   -!- FUNCTION: Complement inhibitor (PubMed:31871188). Prevents complement-
CC       mediated activation of C5 by sterically preventing direct binding of C5
CC       to its convertase (binding with domains MG4 and MG5) (PubMed:31871188)
CC       (By similarity). Binds C5 at a different binding site than the other
CC       tick complement inbibitors OmCI and RaCI3, and the drug eculizumab (By
CC       similarity). Inhibits the complement in human, rat and guinea pig, and
CC       also shows a reduced inhibition in rabbit and pig (By similarity).
CC       {ECO:0000250|UniProtKB:L7MB58, ECO:0000269|PubMed:31871188}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:31871188}.
CC   -!- TISSUE SPECIFICITY: Expressed by the salivary glands.
CC       {ECO:0000305|PubMed:31871188}.
CC   -!- SIMILARITY: Belongs to the CirpT family. {ECO:0000305}.
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DR   EMBL; GT031647; -; NOT_ANNOTATED_CDS; mRNA.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..111
FT                   /note="Complement inhibitor CirpT3"
FT                   /id="PRO_0000456234"
FT   DISULFID        40..64
FT                   /evidence="ECO:0000250|UniProtKB:L7MB58"
FT   DISULFID        59..98
FT                   /evidence="ECO:0000250|UniProtKB:L7MB58"
FT   DISULFID        76..99
FT                   /evidence="ECO:0000250|UniProtKB:L7MB58"
FT   DISULFID        85..104
FT                   /evidence="ECO:0000250|UniProtKB:L7MB58"
SQ   SEQUENCE   111 AA;  11896 MW;  C7D6BCF726909AED CRC64;
     MRTLGVSLFV LVGISAVYCD VQERGHTYVT KNVTVENGAC VFERNVIPDG ETKALNSPCV
     LSTCYAADRK VNSTLCPNFG VAEGCHVEWT PDGEYPNCCP KHVCPAAPAT S