ID   TX20A_AGEOR             Reviewed;          99 AA.
AC   Q5Y4U4;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=U8-agatoxin-Ao1a;
DE            Short=U8-AGTX-Ao1a;
DE   AltName: Full=AgorTX_B6;
DE   Flags: Precursor;
OS   Agelena orientalis (Funnel-web spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Agelenidae; Agelena.
OX   NCBI_TaxID=293813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=15688451; DOI=10.1002/prot.20390;
RA   Kozlov S.A., Malyavka A., McCutchen B., Lu A., Schepers E., Herrmann R.,
RA   Grishin E.V.;
RT   "A novel strategy for the identification of toxinlike structures in spider
RT   venom.";
RL   Proteins 59:131-140(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 5 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 02 (plectoxin) family.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY681341; AAU93682.1; -; mRNA.
DR   AlphaFoldDB; Q5Y4U4; -.
DR   ArachnoServer; AS000072; U8-agatoxin-Ao1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd12960; Spider_toxin; 1.
DR   InterPro; IPR004169; Spidertoxin.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..45
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5000093683"
FT   CHAIN           46..99
FT                   /note="U8-agatoxin-Ao1a"
FT                   /id="PRO_5000093684"
SQ   SEQUENCE   99 AA;  11049 MW;  096CC7A56D1F15A7 CRC64;
     MKSLLFVTIA VYFVAQAVTA NLLSNFLGSS LIDDDKGNMH KLYKRSEDQC IGRSCTCDTS
     STSCCPYAAC RCNLWKTSCK CQRTGRKWAT PCKEIYSPN