ID   TX20A_CTEON             Reviewed;          30 AA.
AC   P85268;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=U10-ctenitoxin-Co1b {ECO:0000305};
DE            Short=U10-CNTX-Co1b {ECO:0000305};
DE   AltName: Full=Neurotoxin Oc M31-11 {ECO:0000303|Ref.1};
DE   Flags: Fragment;
OS   Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Oligoctenus.
OX   NCBI_TaxID=406443;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RA   Borges M.H., Oliveira C.F.B., Goncalves J.M., Rates B., Santos D.M.,
RA   Pimenta A.M.C., Cordeiro M.N., Richardson M.;
RL   Submitted (JUL-2007) to UniProtKB.
CC   -!- FUNCTION: Antagonist of L-type calcium channels (Cav1/CACNA1).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:P30288}.
CC   -!- MASS SPECTROMETRY: Mass=4745; Mass_error=0.04; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the neurotoxin 02 (plectoxin) family.
CC       {ECO:0000255}.
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DR   AlphaFoldDB; P85268; -.
DR   SMR; P85268; -.
DR   ArachnoServer; AS000372; U10-ctenitoxin-Co1b.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004169; Spidertoxin.
DR   Pfam; PF02819; Toxin_9; 1.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated calcium channel impairing toxin.
FT   CHAIN           1..>30
FT                   /note="U10-ctenitoxin-Co1b"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000302121"
FT   DISULFID        2..17
FT                   /evidence="ECO:0000250|UniProtKB:O76201"
FT   DISULFID        9..22
FT                   /evidence="ECO:0000250|UniProtKB:O76201"
FT   DISULFID        16..?
FT                   /evidence="ECO:0000250|UniProtKB:O76201"
FT   DISULFID        24..?
FT                   /evidence="ECO:0000250|UniProtKB:O76201"
FT   NON_TER         30
SQ   SEQUENCE   30 AA;  3489 MW;  5FA15D490F3E95BD CRC64;
     ACVPVYKECW YPQKPCCEDR VCQCSFGMTN