TX20A_LYCSI
ID TX20A_LYCSI Reviewed; 81 AA.
AC B6DD54;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 25-MAY-2022, entry version 24.
DE RecName: Full=U17-lycotoxin-Ls1a {ECO:0000305};
DE Short=U17-LCTX-Ls1a {ECO:0000305};
DE AltName: Full=Toxin-like structure LSTX-P3;
DE Flags: Precursor;
OS Lycosa singoriensis (Wolf spider) (Aranea singoriensis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Lycosidae; Lycosa.
OX NCBI_TaxID=434756;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Venom gland;
RX PubMed=19875276; DOI=10.1016/j.zool.2009.04.001;
RA Zhang Y., Chen J., Tang X., Wang F., Jiang L., Xiong X., Wang M., Rong M.,
RA Liu Z., Liang S.;
RT "Transcriptome analysis of the venom glands of the Chinese wolf spider
RT Lycosa singoriensis.";
RL Zoology 113:10-18(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19875276}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:19875276}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin.
CC {ECO:0000250|UniProtKB:P30288}.
CC -!- SIMILARITY: Belongs to the neurotoxin 02 (plectoxin) family.
CC {ECO:0000305}.
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DR EMBL; EU926138; ACI41470.1; -; mRNA.
DR EMBL; FM864142; CAS03739.1; -; mRNA.
DR AlphaFoldDB; B6DD54; -.
DR ArachnoServer; AS001077; U17-lycotoxin-Ls1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd12960; Spider_toxin; 1.
DR InterPro; IPR004169; Spidertoxin.
DR Pfam; PF02819; Toxin_9; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..34
FT /evidence="ECO:0000250"
FT /id="PRO_0000401899"
FT CHAIN 35..81
FT /note="U17-lycotoxin-Ls1a"
FT /id="PRO_0000401900"
FT DISULFID 36..51
FT /evidence="ECO:0000250|UniProtKB:P30288"
FT DISULFID 50..67
FT /evidence="ECO:0000250|UniProtKB:P30288"
FT DISULFID 58..65
FT /evidence="ECO:0000250|UniProtKB:P30288"
SQ SEQUENCE 81 AA; 8977 MW; 04752AB56BC8F54D CRC64;
MSSKVQAVLL LVGVITFLAV HAQEELSENT ESERSCARLY ERCSMTRRPC CNNVPYVCSL
LGTYCECKKG LIQTVGDFIG I