TX20B_CTEON
ID TX20B_CTEON Reviewed; 37 AA.
AC P85269;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=U10-ctenitoxin-Co1a {ECO:0000305};
DE Short=U10-CNTX-Co1a {ECO:0000305};
DE AltName: Full=Neurotoxin Oc FU-5 {ECO:0000303|Ref.1};
DE Flags: Fragment;
OS Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Oligoctenus.
OX NCBI_TaxID=406443;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC TISSUE=Venom;
RA Borges M.H., Oliveira C.F.B., Goncalves J.M., Rates B., Santos D.M.,
RA Pimenta A.M.C., Cordeiro M.N., Richardson M.;
RL Submitted (JUL-2007) to UniProtKB.
CC -!- FUNCTION: Antagonist of L-type calcium channels (Cav1/CACNA1).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin.
CC {ECO:0000250|UniProtKB:P30288}.
CC -!- MASS SPECTROMETRY: Mass=4761; Mass_error=0.26; Method=Electrospray;
CC Evidence={ECO:0000269|Ref.1};
CC -!- SIMILARITY: Belongs to the neurotoxin 02 (plectoxin) family.
CC {ECO:0000255}.
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DR AlphaFoldDB; P85269; -.
DR SMR; P85269; -.
DR TCDB; 8.B.6.1.4; the ca(2+) channel-targeting spider toxin (cst) family.
DR ArachnoServer; AS000321; U10-ctenitoxin-Co1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd12960; Spider_toxin; 1.
DR InterPro; IPR004169; Spidertoxin.
DR Pfam; PF02819; Toxin_9; 1.
PE 1: Evidence at protein level;
KW Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Toxin;
KW Voltage-gated calcium channel impairing toxin.
FT CHAIN 1..>37
FT /note="U10-ctenitoxin-Co1a"
FT /id="PRO_0000302120"
FT DISULFID 2..17
FT /evidence="ECO:0000250|UniProtKB:O76201"
FT DISULFID 9..22
FT /evidence="ECO:0000250|UniProtKB:O76201"
FT DISULFID 16..33
FT /evidence="ECO:0000250|UniProtKB:O76201"
FT DISULFID 24..31
FT /evidence="ECO:0000250|UniProtKB:O76201"
FT NON_TER 37
SQ SEQUENCE 37 AA; 4292 MW; 88F99DEA8B57B17F CRC64;
ACVPVYKECW YPQKPCCEDR VCQCSFGMTN CKCKARL