TX21A_CTEON
ID TX21A_CTEON Reviewed; 23 AA.
AC P85270;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=U3-ctenitoxin-Co1a {ECO:0000305};
DE Short=U3-CNTX-Co1a {ECO:0000305};
DE AltName: Full=Neurotoxin Oc F29-9 {ECO:0000303|Ref.1};
DE Flags: Fragment;
OS Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Oligoctenus.
OX NCBI_TaxID=406443;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC TISSUE=Venom;
RA Borges M.H., Oliveira C.F.B., Goncalves J.M., Rates B., Santos D.M.,
RA Pimenta A.M.C., Cordeiro M.N., Richardson M.;
RL Submitted (JUL-2007) to UniProtKB.
CC -!- FUNCTION: Antagonist of L-type calcium channels (Cav1/CACNA1).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin.
CC {ECO:0000250|UniProtKB:P30288}.
CC -!- MASS SPECTROMETRY: Mass=4685.8; Mass_error=0.13; Method=Electrospray;
CC Evidence={ECO:0000269|Ref.1};
CC -!- SIMILARITY: Belongs to the neurotoxin 02 (plectoxin) family. 01 (Tx3)
CC subfamily. {ECO:0000255}.
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DR AlphaFoldDB; P85270; -.
DR ArachnoServer; AS000312; U3-ctenitoxin-Co1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004169; Spidertoxin.
DR Pfam; PF02819; Toxin_9; 1.
PE 1: Evidence at protein level;
KW Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Toxin;
KW Voltage-gated calcium channel impairing toxin.
FT CHAIN 1..>23
FT /note="U3-ctenitoxin-Co1a"
FT /id="PRO_0000302118"
FT DISULFID 2..17
FT /evidence="ECO:0000250|UniProtKB:O76200"
FT DISULFID 9..22
FT /evidence="ECO:0000250|UniProtKB:O76200"
FT DISULFID 16..?
FT /evidence="ECO:0000250|UniProtKB:O76200"
FT NON_TER 23
SQ SEQUENCE 23 AA; 2629 MW; A042ECBD7F8C31F3 CRC64;
ACVPVYEECG TPKKRCCEER PCK