ID   TX21A_ETHRU             Reviewed;          68 AA.
AC   P0DPW6;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   10-APR-2019, sequence version 1.
DT   25-MAY-2022, entry version 5.
DE   RecName: Full=U-scoloptoxin(02)-Er1a {ECO:0000303|PubMed:24847043};
DE            Short=U-SLPTX(02)-Er1a {ECO:0000303|PubMed:24847043};
DE   Flags: Precursor;
OS   Ethmostigmus rubripes (Giant centipede).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Ethmostigmus.
OX   NCBI_TaxID=62613;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND NOMENCLATURE.
RC   TISSUE=Venom gland;
RX   PubMed=24847043; DOI=10.1093/molbev/msu162;
RA   Undheim E.A., Jones A., Clauser K.R., Holland J.W., Pineda S.S., King G.F.,
RA   Fry B.G.;
RT   "Clawing through evolution: toxin diversification and convergence in the
RT   ancient lineage Chilopoda (centipedes).";
RL   Mol. Biol. Evol. 31:2124-2148(2014).
CC   -!- FUNCTION: Antibacterial peptide mostly active against Gram-positive
CC       bacteria. {ECO:0000255|PROSITE-ProRule:PRU00710}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24847043}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24847043}.
CC   -!- MISCELLANEOUS: This toxin has also been classified in the scoloptoxin-
CC       02 family. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00710}.
CC   -!- CAUTION: All E.rubripes family members described in 'Undeheim et al.,
CC       2014' have not been imported into UniProtKB. Please, refer to this
CC       paper to access them. {ECO:0000305|PubMed:24847043}.
CC   -!- WEB RESOURCE: Name=National Center for Biotechnology Information
CC       (NCBI);
CC       URL="https://www.ncbi.nlm.nih.gov/nuccore/GASI01000163";
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DR   AlphaFoldDB; P0DPW6; -.
DR   SMR; P0DPW6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..68
FT                   /note="U-scoloptoxin(02)-Er1a"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000446693"
FT   DISULFID        30..52
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        38..58
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        42..60
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
SQ   SEQUENCE   68 AA;  7451 MW;  9F7534FB6572B953 CRC64;
     MIVSLRCCLL LVALLITVET AIMSKRDIVC SVSGDVACNL ECELLHKKKG SCDENGACTC
     FNKKRETE