TX22C_PLETR
ID TX22C_PLETR Reviewed; 79 AA.
AC P36985;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=U1-plectoxin-Pt1c {ECO:0000305};
DE Short=U1-PLTX-Pt1c {ECO:0000305};
DE AltName: Full=Plectoxin XI;
DE Short=PLT-XI;
DE Short=PLTXI;
DE AltName: Full=Plectoxin-11;
DE Flags: Precursor; Fragment;
OS Plectreurys tristis (Spider) (Plectreurys bispinosus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Haplogynae; Pholcoidea; Plectreuridae; Plectreurys.
OX NCBI_TaxID=33319;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=8763160; DOI=10.1016/0965-1748(95)00070-4;
RA Leisy D.J., Mattson J.D., Quistad G.B., Kramer S.J., van Beek N.,
RA Tsai L.W., Enderlin F.E., Woodworth A.R., Digan M.E.;
RT "Molecular cloning and sequencing of cDNAs encoding insecticidal peptides
RT from the primitive hunting spider, Plectreurys tristis (Simon).";
RL Insect Biochem. Mol. Biol. 26:411-417(1996).
RN [2]
RP PROTEIN SEQUENCE OF 32-77, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=8157635; DOI=10.1016/s0021-9258(19)78096-x;
RA Quistad G.B., Skinner W.S.;
RT "Isolation and sequencing of insecticidal peptides from the primitive
RT hunting spider, Plectreurys tristis (Simon).";
RL J. Biol. Chem. 269:11098-11101(1994).
CC -!- FUNCTION: Potent toxin that may paralyze and/or kill insect pests such
CC as H.virescens (lepidoptera), S.exigua (beet armyworm) and M.sexta
CC (tobacco hornworm).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8157635}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:8157635}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the neurotoxin 02 (plectoxin) family. 02
CC (plectoxin) subfamily. {ECO:0000305}.
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DR EMBL; U29270; AAC47201.1; -; mRNA.
DR PIR; C53613; C53613.
DR AlphaFoldDB; P36985; -.
DR SMR; P36985; -.
DR ArachnoServer; AS000392; U1-plectoxin-Pt1c.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004169; Spidertoxin.
DR Pfam; PF02819; Toxin_9; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Knottin; Neurotoxin; Secreted;
KW Signal; Toxin.
FT SIGNAL <1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..31
FT /evidence="ECO:0000269|PubMed:8157635"
FT /id="PRO_0000035539"
FT CHAIN 32..77
FT /note="U1-plectoxin-Pt1c"
FT /evidence="ECO:0000269|PubMed:8157635"
FT /id="PRO_0000035540"
FT PROPEP 78..79
FT /id="PRO_0000035541"
FT DISULFID 35..49
FT /evidence="ECO:0000250|UniProtKB:P83559"
FT DISULFID 42..55
FT /evidence="ECO:0000250|UniProtKB:P83559"
FT DISULFID 48..66
FT /evidence="ECO:0000250|UniProtKB:P83559"
FT DISULFID 52..75
FT /evidence="ECO:0000250|UniProtKB:P83559"
FT DISULFID 57..64
FT /evidence="ECO:0000250|UniProtKB:P83559"
FT NON_TER 1
SQ SEQUENCE 79 AA; 8909 MW; DCDBBAC172033D0B CRC64;
HLILASALIC ALVVCTFAEE QVNVPFLPDE REVKCIGWQE YCRGNLPCCD DCVMCECNIM
GQNCRCNHPR ITSECGSRR