TX261_HUMAN
ID TX261_HUMAN Reviewed; 196 AA.
AC Q6UWH6; A1A587; D6W5G9; Q8WUJ5;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Protein TEX261;
GN Name=TEX261; ORFNames=UNQ1882/PRO4325;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SVP26 family. {ECO:0000305}.
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DR EMBL; AY358783; AAQ89143.1; -; mRNA.
DR EMBL; CH471053; EAW99783.1; -; Genomic_DNA.
DR EMBL; CH471053; EAW99785.1; -; Genomic_DNA.
DR EMBL; BC020251; AAH20251.2; -; mRNA.
DR EMBL; BC128461; AAI28462.1; -; mRNA.
DR EMBL; BC128462; AAI28463.1; -; mRNA.
DR CCDS; CCDS1914.1; -.
DR RefSeq; NP_653183.2; NM_144582.2.
DR AlphaFoldDB; Q6UWH6; -.
DR BioGRID; 125244; 2.
DR IntAct; Q6UWH6; 1.
DR STRING; 9606.ENSP00000272438; -.
DR iPTMnet; Q6UWH6; -.
DR PhosphoSitePlus; Q6UWH6; -.
DR BioMuta; TEX261; -.
DR DMDM; 74749387; -.
DR MassIVE; Q6UWH6; -.
DR PaxDb; Q6UWH6; -.
DR PeptideAtlas; Q6UWH6; -.
DR PRIDE; Q6UWH6; -.
DR ProteomicsDB; 67481; -.
DR Antibodypedia; 16398; 74 antibodies from 13 providers.
DR DNASU; 113419; -.
DR Ensembl; ENST00000272438.9; ENSP00000272438.4; ENSG00000144043.12.
DR GeneID; 113419; -.
DR KEGG; hsa:113419; -.
DR MANE-Select; ENST00000272438.9; ENSP00000272438.4; NM_144582.3; NP_653183.2.
DR UCSC; uc002shn.4; human.
DR CTD; 113419; -.
DR GeneCards; TEX261; -.
DR HGNC; HGNC:30712; TEX261.
DR HPA; ENSG00000144043; Low tissue specificity.
DR MIM; 618562; gene.
DR neXtProt; NX_Q6UWH6; -.
DR OpenTargets; ENSG00000144043; -.
DR PharmGKB; PA134885680; -.
DR VEuPathDB; HostDB:ENSG00000144043; -.
DR eggNOG; KOG4136; Eukaryota.
DR GeneTree; ENSGT00390000010888; -.
DR HOGENOM; CLU_058268_2_0_1; -.
DR InParanoid; Q6UWH6; -.
DR OMA; FEDLPWS; -.
DR OrthoDB; 1338610at2759; -.
DR PhylomeDB; Q6UWH6; -.
DR TreeFam; TF324741; -.
DR PathwayCommons; Q6UWH6; -.
DR SignaLink; Q6UWH6; -.
DR BioGRID-ORCS; 113419; 11 hits in 1057 CRISPR screens.
DR ChiTaRS; TEX261; human.
DR GenomeRNAi; 113419; -.
DR Pharos; Q6UWH6; Tdark.
DR PRO; PR:Q6UWH6; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6UWH6; protein.
DR Bgee; ENSG00000144043; Expressed in islet of Langerhans and 207 other tissues.
DR ExpressionAtlas; Q6UWH6; baseline and differential.
DR Genevisible; Q6UWH6; HS.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0097020; F:COPII receptor activity; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR InterPro; IPR007277; Svp26/Tex261.
DR PANTHER; PTHR13144; PTHR13144; 1.
DR Pfam; PF04148; Erv26; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..196
FT /note="Protein TEX261"
FT /id="PRO_0000247433"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 196 AA; 22538 MW; 9DA21539B227095E CRC64;
MWFMYLLSWL SLFIQVAFIT LAVAAGLYYL AELIEEYTVA TSRIIKYMIW FSTAVLIGLY
VFERFPTSMI GVGLFTNLVY FGLLQTFPFI MLTSPNFILS CGLVVVNHYL AFQFFAEEYY
PFSEVLAYFT FCLWIIPFAF FVSLSAGENV LPSTMQPGDD VVSNYFTKGK RGKRLGILVV
FSFIKEAILP SRQKIY
