TX261_MOUSE
ID TX261_MOUSE Reviewed; 196 AA.
AC Q62302;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Protein TEX261;
DE AltName: Full=Testis-expressed protein 261;
GN Name=Tex261;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=SWR/J; TISSUE=Testis;
RX PubMed=8703127; DOI=10.1007/s003359900210;
RA Lopez-Fernandez L.A., del Mazo J.;
RT "Characterization of genes expressed early in mouse spermatogenesis,
RT isolated from a subtractive cDNA library.";
RL Mamm. Genome 7:698-700(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP DEVELOPMENTAL REGULATION.
RX PubMed=9464256; DOI=10.1006/bbrc.1997.7971;
RA Lopez-Fernandez L.A., Parragao M., del Mazo J.;
RT "Tex261, a novel gene presumably related but distinct from steroidogenic
RT acute regulatory (stAR) gene, is regulated during the development of germ
RT cells.";
RL Biochem. Biophys. Res. Commun. 242:565-569(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in testis. {ECO:0000269|PubMed:8703127}.
CC -!- DEVELOPMENTAL STAGE: Not detectable in testis from 6 day old animals.
CC Detectable in testis 15 days after birth. Highly expressed in testis 20
CC days after birth. Highly expressed in meiotic and post-meiotic germ
CC cells.
CC -!- SIMILARITY: Belongs to the SVP26 family. {ECO:0000305}.
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DR EMBL; X81058; CAA56947.1; -; mRNA.
DR EMBL; AK149789; BAE29086.1; -; mRNA.
DR EMBL; BC003802; AAH03802.1; -; mRNA.
DR CCDS; CCDS20285.1; -.
DR PIR; S47481; S47481.
DR RefSeq; NP_033383.1; NM_009357.2.
DR AlphaFoldDB; Q62302; -.
DR STRING; 10090.ENSMUSP00000014892; -.
DR PhosphoSitePlus; Q62302; -.
DR PaxDb; Q62302; -.
DR PRIDE; Q62302; -.
DR ProteomicsDB; 297758; -.
DR DNASU; 21766; -.
DR Ensembl; ENSMUST00000014892; ENSMUSP00000014892; ENSMUSG00000014748.
DR GeneID; 21766; -.
DR KEGG; mmu:21766; -.
DR UCSC; uc009cof.2; mouse.
DR CTD; 113419; -.
DR MGI; MGI:1096575; Tex261.
DR VEuPathDB; HostDB:ENSMUSG00000014748; -.
DR eggNOG; KOG4136; Eukaryota.
DR GeneTree; ENSGT00390000010888; -.
DR HOGENOM; CLU_058268_2_0_1; -.
DR InParanoid; Q62302; -.
DR OMA; FEDLPWS; -.
DR OrthoDB; 1338610at2759; -.
DR PhylomeDB; Q62302; -.
DR TreeFam; TF324741; -.
DR BioGRID-ORCS; 21766; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Tex261; mouse.
DR PRO; PR:Q62302; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q62302; protein.
DR Bgee; ENSMUSG00000014748; Expressed in ileal epithelium and 257 other tissues.
DR Genevisible; Q62302; MM.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0097020; F:COPII receptor activity; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IGI:MGI.
DR InterPro; IPR007277; Svp26/Tex261.
DR PANTHER; PTHR13144; PTHR13144; 1.
DR Pfam; PF04148; Erv26; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..196
FT /note="Protein TEX261"
FT /id="PRO_0000247434"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 196 AA; 22524 MW; 94ACEE3E5232E6A4 CRC64;
MWFMYVLSWL SLFIQVAFIT LAVAAGLYYL AELIEEYTVA TSRIIKYMIW FSTAVLIGLY
VFERFPTSMI GVGLFTNLVY FGLLQTFPFI MLTSPNFILS CGLVVVNHYL AFQFFAEEYY
PFSEVLAYFT FCLWIIPFAF FVSLSAGENV LPSTMQPGDD VVSNYFTKGK RGKRLGILVV
FSFIKEAILP SRQKIY
