TX27A_CUPSA
ID TX27A_CUPSA Reviewed; 51 AA.
AC B3EWT3;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 1.
DT 25-MAY-2022, entry version 21.
DE RecName: Full=Toxin CSTX-18 {ECO:0000303|PubMed:22672445};
OS Cupiennius salei (American wandering spider).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Cupiennius.
OX NCBI_TaxID=6928;
RN [1]
RP PROTEIN SEQUENCE, MASS SPECTROMETRY, AND DISULFIDE BONDS.
RC TISSUE=Venom;
RX PubMed=22672445; DOI=10.1111/j.1742-4658.2012.08650.x;
RA Trachsel C., Siegemund D., Kampfer U., Kopp L.S., Buhr C., Grossmann J.,
RA Luthi C., Cunningham M., Nentwig W., Kuhn-Nentwig L., Schurch S.,
RA Schaller J.;
RT "Multicomponent venom of the spider Cupiennius salei: a bioanalytical
RT investigation applying different strategies.";
RL FEBS J. 279:2683-2694(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22672445}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:22672445}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin.
CC {ECO:0000250|UniProtKB:P58604}.
CC -!- PTM: Contains 4 disulfide bonds. {ECO:0000269|PubMed:22672445}.
CC -!- MASS SPECTROMETRY: Mass=5598.828; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:22672445};
CC -!- SIMILARITY: Belongs to the neurotoxin 02 (plectoxin) family. 07
CC subfamily. {ECO:0000255}.
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DR AlphaFoldDB; B3EWT3; -.
DR SMR; B3EWT3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004169; Spidertoxin.
DR Pfam; PF02819; Toxin_9; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Knottin; Secreted; Toxin.
FT PEPTIDE 1..51
FT /note="Toxin CSTX-18"
FT /evidence="ECO:0000269|PubMed:22672445"
FT /id="PRO_0000421190"
FT DISULFID 9..22
FT /evidence="ECO:0000250|UniProtKB:P58604"
FT DISULFID 14..27
FT /evidence="ECO:0000250|UniProtKB:P58604"
FT DISULFID 21..36
FT /evidence="ECO:0000250|UniProtKB:P58604"
FT DISULFID 29..34
FT /evidence="ECO:0000250|UniProtKB:P58604"
SQ SEQUENCE 51 AA; 5611 MW; 81A53D20E942BC58 CRC64;
GLWIKGNYCL RGRCLPGGRK CCNGRPCECF AKICSCKPKL IGKLSALKKH T