ID   TX29A_PHONI             Reviewed;          76 AA.
AC   P0C2S9;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=U10-ctenitoxin-Pn1a;
DE            Short=U10-CNTX-Pn1a;
DE   AltName: Full=Neurotoxin Pn3-5A;
DE   Flags: Precursor; Fragment;
OS   Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Phoneutria.
OX   NCBI_TaxID=6918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=12782075; DOI=10.1016/s0041-0101(03)00011-4;
RA   Cardoso F.C., Pacifico L.G., Carvalho D.C., Victoria J.M.N., Neves A.L.G.,
RA   Chavez-Olortegui C., Gomez M.V., Kalapothakis E.;
RT   "Molecular cloning and characterization of Phoneutria nigriventer toxins
RT   active on calcium channels.";
RL   Toxicon 41:755-763(2003).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 02 (plectoxin) family. 09
CC       subfamily.
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DR   AlphaFoldDB; P0C2S9; -.
DR   SMR; P0C2S9; -.
DR   ArachnoServer; AS000264; U10-ctenitoxin-Pn1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Signal.
FT   SIGNAL          <1..15
FT                   /evidence="ECO:0000255"
FT   PROPEP          16..36
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000284878"
FT   CHAIN           38..76
FT                   /note="U10-ctenitoxin-Pn1a"
FT                   /id="PRO_0000284879"
FT   DISULFID        39..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..71
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   76 AA;  8866 MW;  4C8339E765F5DE74 CRC64;
     SFVFYLFTLI TVVRAEEFIL ENEAEDIAPA VHGESGRECI GHRRSCKEDR NGCCRLYTCN
     CWYPTPGDQW CKCQLW