ID   TX2A_MYRBA              Reviewed;          84 AA.
AC   Q68Y22;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=M-myrmeciitoxin-Mb2a {ECO:0000305};
DE            Short=M-MIITX-Mb2a {ECO:0000305};
DE   AltName: Full=M-myrmeciitoxin-Mp3a {ECO:0000303|PubMed:26805882};
DE            Short=M-MIITX-Mp3a {ECO:0000303|PubMed:26805882};
DE   AltName: Full=Pilosulin-4 {ECO:0000303|PubMed:15246874};
DE   Flags: Precursor;
OS   Myrmecia banksi (Jack jumper ant) (Australian jumper ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmeciinae; Myrmeciini; Myrmecia.
OX   NCBI_TaxID=36171;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SYNTHESIS OF 49-84.
RX   PubMed=15246874; DOI=10.1016/j.abb.2004.05.013;
RA   Inagaki H., Akagi M., Imai H.T., Taylor R.W., Kubo T.;
RT   "Molecular cloning and biological characterization of novel antimicrobial
RT   peptides, pilosulin 3 and pilosulin 4, from a species of the Australian ant
RT   genus Myrmecia.";
RL   Arch. Biochem. Biophys. 428:170-178(2004).
RN   [2]
RP   REVIEW, AND NOMENCLATURE.
RX   PubMed=26805882; DOI=10.3390/toxins8010030;
RA   Touchard A., Aili S.R., Fox E.G., Escoubas P., Orivel J., Nicholson G.M.,
RA   Dejean A.;
RT   "The biochemical toxin arsenal from ant venoms.";
RL   Toxins 8:1-28(2016).
CC   -!- FUNCTION: Shows activity against E.coli and S.aureus (MIC<6.25 uM),
CC       moderate activity against P.aeruginosa (MIC<25 uM), weak activity
CC       against B.subtilis (MIC<50 uM), and has no effect against L.garvieae,
CC       C.albicans, and S.cerevisiae. Has no hemolytic nor cytolytic activity.
CC       Causes an IgE-independent histamine release.
CC       {ECO:0000269|PubMed:15246874}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:15246874}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:15246874}.
CC   -!- SIMILARITY: Belongs to the formicidae venom precursor-01 superfamily.
CC       Ant pilosulin family. {ECO:0000305}.
CC   -!- CAUTION: M.banksi is a member of the M.pilosula complex, but is clearly
CC       distinct from M.pilosula species. It is why the nomenclature proposed
CC       by Touchard et al., 2016 is slightly modified in this entry.
CC       {ECO:0000305}.
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DR   EMBL; AB128065; BAD36780.1; -; mRNA.
DR   AlphaFoldDB; Q68Y22; -.
DR   Allergome; 3576; Myr p 3.
DR   Allergome; 3577; Myr p 3.0101.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..48
FT                   /evidence="ECO:0000305|PubMed:15246874"
FT                   /id="PRO_0000035168"
FT   PEPTIDE         49..84
FT                   /note="M-myrmeciitoxin-Mb2a"
FT                   /evidence="ECO:0000305|PubMed:15246874"
FT                   /id="PRO_0000035169"
SQ   SEQUENCE   84 AA;  9019 MW;  78B4A145045E35DC CRC64;
     MKLSCLLLTL AIIFVLTIVH APNVKAKALA DPESDAVGFA DAVGEADPFD ITKLNIKKLT
     KATCKVISKG ASMCKVLFDK KKQE