TX306_LYCSI
ID TX306_LYCSI Reviewed; 115 AA.
AC B6DCQ1;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 25-MAY-2022, entry version 17.
DE RecName: Full=U3-lycotoxin-Ls1u;
DE AltName: Full=Toxin-like structure LSTX-B6;
DE Flags: Precursor;
OS Lycosa singoriensis (Wolf spider) (Aranea singoriensis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Lycosidae; Lycosa.
OX NCBI_TaxID=434756;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Venom gland;
RX PubMed=19875276; DOI=10.1016/j.zool.2009.04.001;
RA Zhang Y., Chen J., Tang X., Wang F., Jiang L., Xiong X., Wang M., Rong M.,
RA Liu Z., Liang S.;
RT "Transcriptome analysis of the venom glands of the Chinese wolf spider
RT Lycosa singoriensis.";
RL Zoology 113:10-18(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurotoxin 19 (CSTX) family. 01 subfamily.
CC {ECO:0000305}.
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DR EMBL; EU925985; ACI41317.1; -; mRNA.
DR EMBL; FM863989; CAS03587.1; -; mRNA.
DR AlphaFoldDB; B6DCQ1; -.
DR SMR; B6DCQ1; -.
DR ArachnoServer; AS000934; U3-lycotoxin-Ls1u.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR011142; Spider_toxin_CSTX_Knottin_CS.
DR PROSITE; PS60029; SPIDER_CSTX; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..44
FT /evidence="ECO:0000250"
FT /id="PRO_0000401617"
FT CHAIN 45..115
FT /note="U3-lycotoxin-Ls1u"
FT /id="PRO_0000401618"
FT DISULFID 48..63
FT /evidence="ECO:0000250"
FT DISULFID 55..72
FT /evidence="ECO:0000250"
FT DISULFID 62..87
FT /evidence="ECO:0000250"
SQ SEQUENCE 115 AA; 13337 MW; 2FD430207D8EAC0D CRC64;
MKFVLLFGVL LVTLFSYSSA EMLDDFDQAD EDELLSLIEK EEARAKECTP RFYDCSHDRH
SCCRSELFKD VCTCFYPEGG DNEVRTCQQP KHLKYMEKAA DKAKKFGGKI KKWFG