ID   TX31D_SCOMU             Reviewed;          75 AA.
AC   I6RU46;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Kappa-scoloptoxin(03)-Ssm1d {ECO:0000305};
DE            Short=Kappa-SLPTX(03)-Ssm1d {ECO:0000305};
DE   AltName: Full=Kappa-scoloptoxin-Ssm1d {ECO:0000303|PubMed:22595790};
DE            Short=Kappa-SLPTX-Ssm1d {ECO:0000303|PubMed:22595790};
DE   Flags: Precursor;
OS   Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra
OS   subspinipes mutilans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX   NCBI_TaxID=2836329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=22595790; DOI=10.1074/mcp.m112.018853;
RA   Yang S., Liu Z., Xiao Y., Li Y., Rong M., Liang S., Zhang Z., Yu H.,
RA   King G.F., Lai R.;
RT   "Chemical punch packed in venoms makes centipedes excellent predators.";
RL   Mol. Cell. Proteomics 11:640-650(2012).
CC   -!- FUNCTION: Inhibits voltage-gated potassium channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:22595790}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:22595790}.
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the scoloptoxin-03 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JQ757071; AFM55018.1; -; mRNA.
DR   AlphaFoldDB; I6RU46; -.
DR   SMR; I6RU46; -.
DR   TCDB; 8.B.26.1.6; the scorpion toxin, scoloptoxin (scoloptoxin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..75
FT                   /note="Kappa-scoloptoxin(03)-Ssm1d"
FT                   /evidence="ECO:0000250|UniProtKB:I6RU32"
FT                   /id="PRO_0000425472"
SQ   SEQUENCE   75 AA;  8503 MW;  555D81047EBE0BA4 CRC64;
     MKLSMAILLV MALIIFTLDK NYSSPKDLPS CEKGIHRKVT CKQCNKRSDN DDDYTKCCKS
     FDAFITCGFL LSKES