C626_CONCL
ID C626_CONCL Reviewed; 64 AA.
AC P0DTY8;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 07-OCT-2020, sequence version 1.
DT 25-MAY-2022, entry version 3.
DE RecName: Full=Conotoxin Cal6.26 {ECO:0000305};
DE AltName: Full=O1_cal6.26 {ECO:0000303|PubMed:30791616};
DE Flags: Precursor;
OS Californiconus californicus (California cone) (Conus californicus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX NCBI_TaxID=1736779;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=30791616; DOI=10.3390/toxins11020128;
RA Bernaldez-Sarabia J., Figueroa-Montiel A., Duenas S., Cervantes-Luevano K.,
RA Beltran J.A., Ortiz E., Jimenez S., Possani L.D., Paniagua-Solis J.F.,
RA Gonzalez-Canudas J., Licea-Navarro A.;
RT "The diversified O-superfamily in Californiconus californicus presents a
RT conotoxin with antimycobacterial activity.";
RL Toxins 11:1-13(2019).
CC -!- FUNCTION: Probable neurotoxin. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:30791616}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:30791616}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000305}.
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DR AlphaFoldDB; P0DTY8; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..64
FT /note="Conotoxin Cal6.26"
FT /evidence="ECO:0000305"
FT /id="PRO_0000450970"
FT DISULFID 32..50
FT /evidence="ECO:0000305"
FT DISULFID 40..54
FT /evidence="ECO:0000305"
FT DISULFID 49..60
FT /evidence="ECO:0000305"
SQ SEQUENCE 64 AA; 7030 MW; E96D44738F1EB262 CRC64;
MKLTCVMIVA VLVLTVCKVV TSDQLKKLRR ECYLEPGDSC FHDDGRGACC EGTCLFGINC
VASW