ID   TX32A_CHIGU             Reviewed;         116 AA.
AC   B1P1I1;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=U30-theraphotoxin-Cg1a;
DE            Short=U30-TRTX-Cg1a;
DE   AltName: Full=Jingzhaotoxin-62;
DE            Short=JZTX-62;
DE   Flags: Precursor;
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18581053; DOI=10.1007/s00018-008-8135-x;
RA   Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.;
RT   "Molecular diversity and evolution of cystine knot toxins of the tarantula
RT   Chilobrachys jingzhao.";
RL   Cell. Mol. Life Sci. 65:2431-2444(2008).
CC   -!- FUNCTION: Probable ion channel inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 03 (Tx2) family. 02 subfamily.
CC       HNTX-XV sub-subfamily. {ECO:0000305}.
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DR   EMBL; EU233912; ABY71731.1; -; mRNA.
DR   AlphaFoldDB; B1P1I1; -.
DR   ArachnoServer; AS000860; U30-theraphotoxin-Cg1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..53
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000398538"
FT   PEPTIDE         54..116
FT                   /note="U30-theraphotoxin-Cg1a"
FT                   /id="PRO_0000398539"
FT   REGION          24..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        55..69
FT                   /evidence="ECO:0000305"
FT   DISULFID        62..75
FT                   /evidence="ECO:0000305"
FT   DISULFID        66..112
FT                   /evidence="ECO:0000305"
FT   DISULFID        68..88
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   116 AA;  12743 MW;  D11EB501FD5F5845 CRC64;
     MKLCVLTIAS LLVTVTSLET QKEIAEGSEL TREETPSLVE HKEDEAAAAS EKRSCIEEWK
     TCEHSCECCG SSTICSSTWA EGKEIKLCKN EGGTFKKVLH FIQKGISKLK SCKEGN