ID   TX32C_CHIGU             Reviewed;         115 AA.
AC   B1P1I4;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=U31-theraphotoxin-Cg1b;
DE            Short=U31-TRTX-Cg1b;
DE   AltName: Full=Jingzhaotoxin-65;
DE            Short=JZTX-65;
DE   Flags: Precursor;
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18581053; DOI=10.1007/s00018-008-8135-x;
RA   Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.;
RT   "Molecular diversity and evolution of cystine knot toxins of the tarantula
RT   Chilobrachys jingzhao.";
RL   Cell. Mol. Life Sci. 65:2431-2444(2008).
CC   -!- FUNCTION: Probable ion channel inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 03 (Tx2) family. 02 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; EU233915; ABY71734.1; -; mRNA.
DR   AlphaFoldDB; B1P1I4; -.
DR   ArachnoServer; AS000863; U31-theraphotoxin-Cg1b.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..51
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000398544"
FT   PEPTIDE         52..115
FT                   /note="U31-theraphotoxin-Cg1b"
FT                   /id="PRO_0000398545"
FT   DISULFID        52..67
FT                   /evidence="ECO:0000305"
FT   DISULFID        60..73
FT                   /evidence="ECO:0000305"
FT   DISULFID        64..113
FT                   /evidence="ECO:0000305"
FT   DISULFID        66..86
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   115 AA;  12866 MW;  93C219EF6DD2021E CRC64;
     MKLCVIIIAS LMVASVSGRL RKIKGTELDK KMLLEKLGHG MDIRFEETPR ECSKKAGEKC
     ESNCDCCGYS TLCGYITEGK EVKYQCMSKT SNNEILNTIG LGMNAIENMF SFCFR