ID   TX32D_CYRHA             Reviewed;         117 AA.
AC   D2Y2B9;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Hainantoxin-XV-3;
DE            Short=HNTX-XV-3;
DE   Flags: Precursor;
OS   Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Haplopelma.
OX   NCBI_TaxID=209901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=20192277; DOI=10.1021/pr1000016;
RA   Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA   Liang S.;
RT   "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT   hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT   and genomic analyses.";
RL   J. Proteome Res. 9:2550-2564(2010).
CC   -!- FUNCTION: Putative ion channel inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 03 (Tx2) family. 02 subfamily.
CC       HNTX-XV sub-subfamily.
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DR   EMBL; GU292996; ADB56812.1; -; mRNA.
DR   AlphaFoldDB; D2Y2B9; -.
DR   ArachnoServer; AS001709; U10-theraphotoxin-Hhn1c.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..56
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000401021"
FT   PEPTIDE         57..117
FT                   /note="Hainantoxin-XV-3"
FT                   /id="PRO_0000401022"
FT   REGION          20..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        58..72
FT                   /evidence="ECO:0000305"
FT   DISULFID        65..78
FT                   /evidence="ECO:0000305"
FT   DISULFID        69..115
FT                   /evidence="ECO:0000305"
FT   DISULFID        71..91
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   117 AA;  13076 MW;  C759B7A805980107 CRC64;
     MKLCAVIIAS LLVCVAVASS SDNQKEFAQE KEMTREETQS LGEHEKDDEV TGSEERSCIE
     EWKTCENDCE CCGMSTLCAA SWVDGHEIKL CRNEGGKLKK VLHFIQKSVS KIRSCKK