ID   TX33A_SCOMU             Reviewed;          32 AA.
AC   P0DMD2;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Mu-scoloptoxin(03)-Ssm3a {ECO:0000305};
DE            Short=Mu-SLPTX(03)-Ssm3a {ECO:0000305};
DE   AltName: Full=Mu-scoloptoxin-Ssm1a {ECO:0000303|PubMed:22595790};
DE            Short=Mu-SLPTX-Ssm1a {ECO:0000303|PubMed:22595790};
OS   Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra
OS   subspinipes mutilans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX   NCBI_TaxID=2836329;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, BIOASSAY, DISULFIDE BONDS, LETHAL DOSES, MASS
RP   SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=22595790; DOI=10.1074/mcp.m112.018853;
RA   Yang S., Liu Z., Xiao Y., Li Y., Rong M., Liang S., Zhang Z., Yu H.,
RA   King G.F., Lai R.;
RT   "Chemical punch packed in venoms makes centipedes excellent predators.";
RL   Mol. Cell. Proteomics 11:640-650(2012).
CC   -!- FUNCTION: Toxin that specifically inhibits tetrodotoxin-sensitive
CC       voltage-gated sodium channels (Nav) (IC(50) of =about 9 nM). In vivo,
CC       insects injected with this toxin showed signs of neurotoxicity
CC       including twitching, paralysis, and body contraction.
CC       {ECO:0000269|PubMed:22595790}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22595790}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:22595790}.
CC   -!- PTM: Contains 2 disulfide bonds. {ECO:0000269|PubMed:22595790}.
CC   -!- MASS SPECTROMETRY: Mass=3762.5; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:22595790};
CC   -!- TOXIC DOSE: The LD(50) ranges from 0.25 mg/kg in adult blowflies to
CC       23.7 mg/kg in cockroaches;. {ECO:0000269|PubMed:22595790}.
CC   -!- SIMILARITY: Belongs to the scoloptoxin-03 family. {ECO:0000305}.
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DR   AlphaFoldDB; P0DMD2; -.
DR   SMR; P0DMD2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..32
FT                   /note="Mu-scoloptoxin(03)-Ssm3a"
FT                   /evidence="ECO:0000269|PubMed:22595790"
FT                   /id="PRO_0000425468"
FT   DISULFID        15..31
FT                   /evidence="ECO:0000250|UniProtKB:P0DL36"
FT   DISULFID        18..24
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   32 AA;  3767 MW;  16F4B47B48E2D54C CRC64;
     ADNKFENSLR REIACGQCRD KVKCDPYFYH CG