ID   TX35C_CTEON             Reviewed;          28 AA.
AC   P85264;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=U15-ctenitoxin-Co1a {ECO:0000305};
DE            Short=U15-CNTX-Co1a {ECO:0000305};
DE   AltName: Full=Neurotoxin Oc M33-7 {ECO:0000303|Ref.1};
DE   Flags: Fragment;
OS   Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Oligoctenus.
OX   NCBI_TaxID=406443;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RA   Borges M.H., Oliveira C.F.B., Goncalves J.M., Rates B., Santos D.M.,
RA   Pimenta A.M.C., Cordeiro M.N., Richardson M.;
RL   Submitted (JUL-2007) to UniProtKB.
CC   -!- FUNCTION: Insecticidal neurotoxin that reversibly inhibits the N-
CC       methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor
CC       (GRIN) and inhibits inactivation of insect sodium channels (Nav). In
CC       vivo, is highly toxic to insects. {ECO:0000250|UniProtKB:P59367}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=5460; Mass_error=0.37; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the neurotoxin 03 (Tx2) family. 05 subfamily.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P85264; -.
DR   SMR; P85264; -.
DR   ArachnoServer; AS000373; U15-ctenitoxin-Co1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Ionotropic glutamate receptor inhibitor; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..>28
FT                   /note="U15-ctenitoxin-Co1a"
FT                   /evidence="ECO:0000305|Ref.1"
FT                   /id="PRO_0000302113"
FT   DISULFID        3..17
FT                   /evidence="ECO:0000305"
FT   DISULFID        10..22
FT                   /evidence="ECO:0000305"
FT   DISULFID        14..?
FT                   /evidence="ECO:0000305"
FT   DISULFID        16..?
FT                   /evidence="ECO:0000305"
FT   DISULFID        24..?
FT                   /evidence="ECO:0000305"
FT   NON_TER         28
SQ   SEQUENCE   28 AA;  2994 MW;  D3F86BEC802D7D76 CRC64;
     GKCGDINAPC KAECDCCGYT TCDCYWGN