TX36A_CTEON
ID TX36A_CTEON Reviewed; 18 AA.
AC P85235;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 25-MAY-2022, entry version 19.
DE RecName: Full=U11-ctenitoxin-Co1a;
DE Short=U11-CNTX-Co1a;
DE AltName: Full=Neurotoxin Oc M10-6;
DE Flags: Fragment;
OS Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Oligoctenus.
OX NCBI_TaxID=406443;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP SPECTROMETRY.
RC TISSUE=Venom;
RA Borges M.H., Oliveira C.F.B., Goncalves J.M., Rates B., Santos D.M.,
RA Pimenta A.M.C., Cordeiro M.N., Richardson M.;
RL Submitted (JUL-2007) to UniProtKB.
CC -!- FUNCTION: Neurotoxin. {ECO:0000250|UniProtKB:P83896}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=4654.7; Mass_error=0.07; Method=Electrospray;
CC Evidence={ECO:0000269|Ref.1};
CC -!- SIMILARITY: Belongs to the neurotoxin 03 (Tx2) family. 06 subfamily.
CC {ECO:0000305}.
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DR AlphaFoldDB; P85235; -.
DR ArachnoServer; AS000362; U11-ctenitoxin-Co1a (N-terminal fragment).
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Knottin; Neurotoxin; Secreted;
KW Toxin.
FT PEPTIDE 1..>18
FT /note="U11-ctenitoxin-Co1a"
FT /id="PRO_0000302110"
FT DISULFID 3..17
FT /evidence="ECO:0000305"
FT DISULFID 10..?
FT /evidence="ECO:0000305"
FT DISULFID 16..?
FT /evidence="ECO:0000305"
FT NON_TER 18
SQ SEQUENCE 18 AA; 2008 MW; E545D4ABA0DCA5F4 CRC64;
KKCADIDQDC KTSCDCCE