ID   TX36C_CTEON             Reviewed;          31 AA.
AC   P85275;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   23-FEB-2022, entry version 26.
DE   RecName: Full=U8-ctenitoxin-Co1a;
DE            Short=U8-CNTX-Co1a;
DE   AltName: Full=Neurotoxin Oc F40-6;
DE   Flags: Fragment;
OS   Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Oligoctenus.
OX   NCBI_TaxID=406443;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom;
RA   Borges M.H., Oliveira C.F.B., Goncalves J.M., Rates B., Santos D.M.,
RA   Pimenta A.M.C., Cordeiro M.N., Richardson M.;
RL   Submitted (JUL-2007) to UniProtKB.
CC   -!- FUNCTION: Blocks voltage-gated sodium channels (Nav). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=5818.4; Mass_error=0.3; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the neurotoxin 03 (Tx2) family. 06 subfamily.
CC       {ECO:0000305}.
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DR   ArachnoServer; AS000316; U8-ctenitoxin-Co1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR035285; CNTX.
DR   Pfam; PF17492; D_CNTX; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Knottin; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..>31
FT                   /note="U8-ctenitoxin-Co1a"
FT                   /id="PRO_0000302117"
FT   DISULFID        4..18
FT                   /evidence="ECO:0000305"
FT   DISULFID        11..24
FT                   /evidence="ECO:0000305"
FT   DISULFID        15..?
FT                   /evidence="ECO:0000305"
FT   DISULFID        17..?
FT                   /evidence="ECO:0000305"
FT   NON_TER         31
SQ   SEQUENCE   31 AA;  3241 MW;  35B6BDC0A73CD17D CRC64;
     DGKCAGQDKP CKNSCDCCGA RGECVYTGYX P