TX3AB_DINQU
ID TX3AB_DINQU Reviewed; 20 AA.
AC C0HJK0;
DT 03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT 03-SEP-2014, sequence version 1.
DT 25-MAY-2022, entry version 12.
DE RecName: Full=Poneritoxin {ECO:0000305};
DE AltName: Full=Poneratoxin {ECO:0000305};
DE AltName: Full=Venom peptides {ECO:0000303|PubMed:24157790};
DE Contains:
DE RecName: Full=U1-poneritoxin-Dq3e {ECO:0000303|PubMed:26805882};
DE Short=U1-PONTX-Dq3e {ECO:0000303|PubMed:26805882};
DE AltName: Full=Peptide Dq-1984 {ECO:0000303|PubMed:24157790};
DE Contains:
DE RecName: Full=U1-poneritoxin-Dq3d {ECO:0000303|PubMed:26805882};
DE Short=U1-PONTX-Dq3d {ECO:0000303|PubMed:26805882};
DE AltName: Full=Peptide Dq-1897 {ECO:0000303|PubMed:24157790};
DE Contains:
DE RecName: Full=U1-poneritoxin-Dq3a/U1-poneritoxin-Dq3b/U1-poneritoxin-Dq3c {ECO:0000303|PubMed:26805882};
DE Short=U1-PONTX-Dq3a/U1-PONTX-Dq3b/U1-PONTX-Dq3c {ECO:0000303|PubMed:26805882};
DE AltName: Full=Peptide Dq-1839/Dq-1840/Dq-1856 {ECO:0000303|PubMed:24157790};
OS Dinoponera quadriceps (South American ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Dinoponera.
OX NCBI_TaxID=609295;
RN [1]
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, OXIDATION AT
RP MET-18, AND AMIDATION AT LYS-19.
RC TISSUE=Venom;
RX PubMed=24157790; DOI=10.1016/j.jprot.2013.10.017;
RA Cologna C.T., Cardoso Jdos S., Jourdan E., Degueldre M., Upert G.,
RA Gilles N., Uetanabaro A.P., Costa Neto E.M., Thonart P., de Pauw E.,
RA Quinton L.;
RT "Peptidomic comparison and characterization of the major components of the
RT venom of the giant ant Dinoponera quadriceps collected in four different
RT areas of Brazil.";
RL J. Proteomics 94:413-422(2013).
RN [2]
RP REVIEW, AND NOMENCLATURE.
RX PubMed=26805882; DOI=10.3390/toxins8010030;
RA Touchard A., Aili S.R., Fox E.G., Escoubas P., Orivel J., Nicholson G.M.,
RA Dejean A.;
RT "The biochemical toxin arsenal from ant venoms.";
RL Toxins 8:1-28(2016).
CC -!- FUNCTION: [U1-poneritoxin-Dq3e]: May have antimicrobial properties,
CC like most ant linear peptides. {ECO:0000305}.
CC -!- FUNCTION: [U1-poneritoxin-Dq3d]: May have antimicrobial properties,
CC like most ant linear peptides. {ECO:0000305}.
CC -!- FUNCTION: [U1-poneritoxin-Dq3a/U1-poneritoxin-Dq3b/U1-poneritoxin-
CC Dq3c]: May have antimicrobial properties, like most ant linear
CC peptides. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24157790}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:24157790}.
CC -!- PTM: The peptide spanning residues 2 to 19 occurs in 3 forms and has
CC been given 3 different names. U1-PONTX-Dq3a has an amidated Lys-19, U1-
CC PONTX-Dq3c has an amidated Lys-19 and an oxidized Met-18, and U1-PONTX-
CC Dq3b has no modifications at either Met-18 or Lys-19.
CC {ECO:0000269|PubMed:24157790}.
CC -!- MASS SPECTROMETRY: [U1-poneritoxin-Dq3e]: Mass=1984.2;
CC Method=Electrospray; Note=U1-PONTX-Dq3e.;
CC Evidence={ECO:0000269|PubMed:24157790};
CC -!- MASS SPECTROMETRY: [U1-poneritoxin-Dq3d]: Mass=1897.2;
CC Method=Electrospray; Note=U1-PONTX-Dq3d.;
CC Evidence={ECO:0000269|PubMed:24157790};
CC -!- MASS SPECTROMETRY: [U1-poneritoxin-Dq3a/U1-poneritoxin-Dq3b/U1-
CC poneritoxin-Dq3c]: Mass=1839.1; Method=Electrospray; Note=U1-PONTX-
CC Dq3a.; Evidence={ECO:0000269|PubMed:24157790};
CC -!- MASS SPECTROMETRY: [U1-poneritoxin-Dq3a/U1-poneritoxin-Dq3b/U1-
CC poneritoxin-Dq3c]: Mass=1840.1; Method=Electrospray; Note=U1-PONTX-
CC Dq3b.; Evidence={ECO:0000269|PubMed:24157790};
CC -!- MASS SPECTROMETRY: [U1-poneritoxin-Dq3a/U1-poneritoxin-Dq3b/U1-
CC poneritoxin-Dq3c]: Mass=1856.1; Method=Electrospray; Note=U1-PONTX-
CC Dq3c.; Evidence={ECO:0000269|PubMed:24157790};
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DR AlphaFoldDB; C0HJK0; -.
DR Proteomes; UP000515204; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Amidation; Antimicrobial; Direct protein sequencing; Oxidation;
KW Reference proteome; Secreted.
FT PEPTIDE 1..19
FT /note="U1-poneritoxin-Dq3e"
FT /evidence="ECO:0000269|PubMed:24157790"
FT /id="PRO_0000430023"
FT PEPTIDE 3..20
FT /note="U1-poneritoxin-Dq3d"
FT /evidence="ECO:0000269|PubMed:24157790"
FT /id="PRO_0000430024"
FT PEPTIDE 3..19
FT /note="U1-poneritoxin-Dq3a/U1-poneritoxin-Dq3b/U1-
FT poneritoxin-Dq3c"
FT /evidence="ECO:0000269|PubMed:24157790"
FT /id="PRO_0000430025"
FT MOD_RES 18
FT /note="Methionine sulfoxide; in form U1-PONTX-Dq3c"
FT /evidence="ECO:0000269|PubMed:24157790"
FT MOD_RES 19
FT /note="Lysine amide; in form U1-PONTX-Dq3a and U1-PONTX-
FT Dq3c"
FT /evidence="ECO:0000269|PubMed:24157790"
FT UNSURE 3
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:24157790"
FT UNSURE 6
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:24157790"
FT UNSURE 10
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:24157790"
FT UNSURE 11
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:24157790"
FT UNSURE 13
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:24157790"
FT UNSURE 17
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:24157790"
SQ SEQUENCE 20 AA; 2043 MW; C72D379E3B6AA2E3 CRC64;
GSLVKLVSTL LSLVPSLMKG
