ID   TX3A_MYRBA              Reviewed;          91 AA.
AC   A9CM07;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=M-myrmeciitoxin-Mb3a {ECO:0000305};
DE            Short=M-MIITX-Mb3a {ECO:0000305};
DE   AltName: Full=M-myrmeciitoxin-Mp4a {ECO:0000303|PubMed:26805882};
DE            Short=M-MIITX-Mp4a {ECO:0000303|PubMed:26805882};
DE   AltName: Full=Myrb5 {ECO:0000312|EMBL:BAF95069.1};
DE   AltName: Full=Pilosulin-5 {ECO:0000303|PubMed:18544336};
DE   Flags: Precursor;
OS   Myrmecia banksi (Jack jumper ant) (Australian jumper ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmeciinae; Myrmeciini; Myrmecia.
OX   NCBI_TaxID=36171;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 55-91, FUNCTION, IDENTIFICATION BY
RP   MASS SPECTROMETRY, DISULFIDE BOND, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=18544336; DOI=10.1016/j.abb.2008.05.014;
RA   Inagaki H., Akagi M., Imai H.T., Taylor R.W., Wiese M.D., Davies N.W.,
RA   Kubo T.;
RT   "Pilosulin 5, a novel histamine-releasing peptide of the Australian ant,
RT   Myrmecia pilosula (Jack Jumper Ant).";
RL   Arch. Biochem. Biophys. 477:411-416(2008).
RN   [2]
RP   MASS SPECTROMETRY, AND SUBUNIT.
RC   TISSUE=Venom;
RX   PubMed=16376960; DOI=10.1016/j.toxicon.2005.10.018;
RA   Wiese M.D., Chataway T.K., Davies N.W., Milne R.W., Brown S.G., Gai W.P.,
RA   Heddle R.J.;
RT   "Proteomic analysis of Myrmecia pilosula (jack jumper) ant venom.";
RL   Toxicon 47:208-217(2006).
RN   [3]
RP   REVIEW, AND NOMENCLATURE.
RX   PubMed=26805882; DOI=10.3390/toxins8010030;
RA   Touchard A., Aili S.R., Fox E.G., Escoubas P., Orivel J., Nicholson G.M.,
RA   Dejean A.;
RT   "The biochemical toxin arsenal from ant venoms.";
RL   Toxins 8:1-28(2016).
CC   -!- FUNCTION: Causes a significant and dose-dependent histamine release,
CC       probably by influencing the signal transduction of mast cells through a
CC       non-IgE-mediated pathway. This peptide does not have cytotoxic
CC       activities. {ECO:0000269|PubMed:18544336}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000269|PubMed:16376960,
CC       ECO:0000269|PubMed:18544336}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18544336}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland and reservoir.
CC       {ECO:0000269|PubMed:18544336}.
CC   -!- MASS SPECTROMETRY: Mass=4274; Method=Unknown;
CC       Evidence={ECO:0000269|PubMed:16376960};
CC   -!- SIMILARITY: Belongs to the formicidae venom precursor-01 superfamily.
CC       Ant pilosulin family. {ECO:0000305}.
CC   -!- CAUTION: M.banksi is a member of the M.pilosula complex, but is clearly
CC       distinct from M.pilosula species. It is why the nomenclature proposed
CC       by Touchard et al., 2016 is slightly modified in this entry.
CC       {ECO:0000305}.
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DR   EMBL; AB219975; BAF95069.1; -; mRNA.
DR   AlphaFoldDB; A9CM07; -.
DR   SMR; A9CM07; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..54
FT                   /evidence="ECO:0000305|PubMed:18544336"
FT                   /id="PRO_0000412825"
FT   CHAIN           55..91
FT                   /note="M-myrmeciitoxin-Mb3a"
FT                   /evidence="ECO:0000305|PubMed:18544336"
FT                   /id="PRO_5000287686"
FT   DISULFID        69
FT                   /note="Interchain"
FT                   /evidence="ECO:0000269|PubMed:18544336"
SQ   SEQUENCE   91 AA;  9816 MW;  D0A25809A5D1EBA6 CRC64;
     MKLSCLSLAL AIILILAIVH SPNMEVKALA DPEADAFGEA NAFGEADAFA EANADVKGMK
     KAIKEILDCV IEKGYDKLAA KLKKVIQQLW E