ID   TX4A_CHEPU              Reviewed;          20 AA.
AC   C0HKG4;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Toxin CpTx-4a {ECO:0000303|PubMed:24717175};
DE   Flags: Fragment;
OS   Cheiracanthium punctorium (Yellow sac spider) (Aranea punctoria).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Entelegynae incertae sedis; Cheiracanthiidae;
OC   Cheiracanthium.
OX   NCBI_TaxID=682790 {ECO:0000303|PubMed:24717175};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY,
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND TOXIC DOSE.
RC   TISSUE=Venom {ECO:0000303|PubMed:24717175};
RX   PubMed=24717175; DOI=10.1111/imb.12097;
RA   Sachkova M.Y., Slavokhotova A.A., Grishin E.V., Vassilevski A.A.;
RT   "Structure of the yellow sac spider Cheiracanthium punctorium genes
RT   provides clues to evolution of insecticidal two-domain knottin toxins.";
RL   Insect Mol. Biol. 23:527-538(2014).
CC   -!- FUNCTION: Spider venom toxin that exhibits cytolytic activity by
CC       forming an alpha-helix across the membrane (By similarity). Lethal to
CC       insect larvae (PubMed:24717175). {ECO:0000250|UniProtKB:C0HKG7,
CC       ECO:0000269|PubMed:24717175}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24717175}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24717175}.
CC   -!- MASS SPECTROMETRY: Mass=15080; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:24717175};
CC   -!- TOXIC DOSE: LD(50) is 33-50 ug/g in S.carnaria larvae.
CC       {ECO:0000269|PubMed:24717175}.
CC   -!- TOXIC DOSE: PD(50) is 25-33 ug/g in S.carnaria larvae.
CC       {ECO:0000269|PubMed:24717175}.
CC   -!- SIMILARITY: Belongs to the spider toxin CSTX family. {ECO:0000305}.
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DR   AlphaFoldDB; C0HKG4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted; Toxin.
FT   CHAIN           1..>20
FT                   /note="Toxin CpTx-4a"
FT                   /evidence="ECO:0000269|PubMed:24717175"
FT                   /id="PRO_0000440160"
FT   NON_TER         20
FT                   /evidence="ECO:0000303|PubMed:24717175"
SQ   SEQUENCE   20 AA;  2294 MW;  F24140843DF114C5 CRC64;
     ASCTERKHDC TKDRHSCCRG