ID   TX4A_DINQU              Reviewed;          28 AA.
AC   C0HJH7;
DT   03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT   03-SEP-2014, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=M-poneritoxin-Dq4a {ECO:0000303|PubMed:26805882};
DE            Short=M-PONTX-Dq4a {ECO:0000303|PubMed:26805882};
DE   AltName: Full=Dinoponeratoxin Dq-3104 {ECO:0000303|PubMed:24157790};
DE   AltName: Full=Poneratoxin {ECO:0000305};
OS   Dinoponera quadriceps (South American ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Dinoponera.
OX   NCBI_TaxID=609295;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY,
RP   SYNTHESIS, MUTAGENESIS OF 19-ASP--SER-20, AND AMIDATION AT ALA-28.
RC   TISSUE=Venom;
RX   PubMed=24157790; DOI=10.1016/j.jprot.2013.10.017;
RA   Cologna C.T., Cardoso Jdos S., Jourdan E., Degueldre M., Upert G.,
RA   Gilles N., Uetanabaro A.P., Costa Neto E.M., Thonart P., de Pauw E.,
RA   Quinton L.;
RT   "Peptidomic comparison and characterization of the major components of the
RT   venom of the giant ant Dinoponera quadriceps collected in four different
RT   areas of Brazil.";
RL   J. Proteomics 94:413-422(2013).
RN   [2]
RP   REVIEW, AND NOMENCLATURE.
RX   PubMed=26805882; DOI=10.3390/toxins8010030;
RA   Touchard A., Aili S.R., Fox E.G., Escoubas P., Orivel J., Nicholson G.M.,
RA   Dejean A.;
RT   "The biochemical toxin arsenal from ant venoms.";
RL   Toxins 8:1-28(2016).
CC   -!- FUNCTION: The synthetic peptide has weak antimicrobial activity against
CC       Gram-negative bacterium E.coli ATCC 10536 (PubMed:24157790). It does
CC       not show antimicrobial activity against the Gram-positive bacteria
CC       B.amyloliquefacies S499, L.monocytogenes 2231 and S.aureus ATCC 29213,
CC       against the Gram-negative bacteria P.putida BTP1 and P.aeruginosa PaO1,
CC       or against the fungi S.cerevisiae, R.mucilaginosa, C.cucumerinum,
CC       F.oxysporum and B.cinerea (PubMed:24157790).
CC       {ECO:0000269|PubMed:24157790}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24157790}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24157790}.
CC   -!- MASS SPECTROMETRY: Mass=3104; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:24157790};
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DR   AlphaFoldDB; C0HJH7; -.
DR   Proteomes; UP000515204; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing;
KW   Reference proteome; Secreted; Toxin.
FT   PEPTIDE         1..28
FT                   /note="M-poneritoxin-Dq4a"
FT                   /evidence="ECO:0000269|PubMed:24157790"
FT                   /id="PRO_0000430021"
FT   MOD_RES         28
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000269|PubMed:24157790"
FT   MUTAGEN         19..20
FT                   /note="DS->EM: No effect on antimicrobial activity."
FT                   /evidence="ECO:0000269|PubMed:24157790"
FT   UNSURE          2
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:24157790"
FT   UNSURE          13
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:24157790"
FT   UNSURE          25
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:24157790"
SQ   SEQUENCE   28 AA;  3108 MW;  1491FB0C71072249 CRC64;
     GLKDWWNKHK DKIVEVVKDS GKAGLNAA