ID   TX4_LOXIN               Reviewed;          81 AA.
AC   Q27Q53;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=U1-sicaritoxin-Li1c;
DE            Short=U1-SCRTX-Li1c;
DE   AltName: Full=LiTx4 {ECO:0000303|Ref.1};
DE   Flags: Precursor; Fragment;
OS   Loxosceles intermedia (Brown spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Haplogynae; Scytodoidea; Sicariidae; Loxosceles.
OX   NCBI_TaxID=58218;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   de Moura J.F., Kalapothakis E., Chavez-Olortegui C.;
RT   "Molecular cloning and systematic screening of cDNA encoding for three
RT   toxins from Loxosceles intermedia venom gland.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Toxin active against insects (S.frugiperda larvae). May act
CC       on sodium (Nav) or calcium (Cav) channels.
CC       {ECO:0000250|UniProtKB:Q6B4T5}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6B4T5}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 28 (Litx) family. {ECO:0000305}.
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DR   EMBL; DQ388598; ABD48090.1; -; mRNA.
DR   AlphaFoldDB; Q27Q53; -.
DR   ArachnoServer; AS000283; U1-sicaritoxin-Li1c.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Calcium channel impairing toxin;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated calcium channel impairing toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   PROPEP          <1..16
FT                   /id="PRO_0000262663"
FT   CHAIN           17..62
FT                   /note="U1-sicaritoxin-Li1c"
FT                   /id="PRO_0000262664"
FT   PROPEP          66..81
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000262665"
FT   MOD_RES         62
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        18..35
FT                   /evidence="ECO:0000250"
FT   DISULFID        26..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..51
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   81 AA;  9363 MW;  370F82D044546166 CRC64;
     ARGDAEKWES LISEERACKG EGVKGCYDKP DDWCCKKTPC KCPAWSHERE CRCTQPCARR
     CRGKRALMLD PETHRLLFSE D