ID   TX5_SELPU               Reviewed;          78 AA.
AC   P0DM69;
DT   13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2013, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Toxin OAIP 5;
DE   Flags: Precursor;
OS   Selenotypus plumipes (Australian featherleg tarantula).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Selenotypus.
OX   NCBI_TaxID=1395661;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=23894279; DOI=10.1371/journal.pone.0066279;
RA   Wong E.S., Hardy M.C., Wood D., Bailey T., King G.F.;
RT   "SVM-based prediction of propeptide cleavage sites in spider toxins
RT   identifies toxin innovation in an australian tarantula.";
RL   PLoS ONE 8:E66279-E66279(2013).
CC   -!- FUNCTION: Probable ion channel inhibitor. Shows insecticidal activity
CC       when injected into mealworms. {ECO:0000269|PubMed:23894279}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 05 (OAIP-5)
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0DM69; -.
DR   SMR; P0DM69; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012625; Toxin_20.
DR   Pfam; PF08089; Toxin_20; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..40
FT                   /id="PRO_0000424400"
FT   CHAIN           41..78
FT                   /note="Toxin OAIP 5"
FT                   /id="PRO_0000424401"
FT   DISULFID        43..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..70
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..75
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8723 MW;  6105AD8603773F55 CRC64;
     MLIVILTCAL LVIYHAAAAE ELEAKDVIES KALATLDEER FECVLKCDIQ YNGKNCKGKG
     ENKCSGGWRC RFKLCLKI