ID   TX72A_SCOMU             Reviewed;          74 AA.
AC   I6RA66;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Kappa-scoloptoxin(07)-Ssm2a {ECO:0000303|PubMed:24847043};
DE            Short=Kappa-SLPTX(07)-Ssm2a {ECO:0000303|PubMed:24847043};
DE   AltName: Full=Kappa-scoloptoxin-Ssm2a {ECO:0000303|PubMed:22595790};
DE            Short=Kappa-SLPTX-Ssm2a {ECO:0000303|PubMed:22595790};
DE   Flags: Precursor;
OS   Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra
OS   subspinipes mutilans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX   NCBI_TaxID=2836329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 44-74, FUNCTION, BIOASSAY,
RP   TOXIC DOSE, DISULFIDE BONDS, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=22595790; DOI=10.1074/mcp.m112.018853;
RA   Yang S., Liu Z., Xiao Y., Li Y., Rong M., Liang S., Zhang Z., Yu H.,
RA   King G.F., Lai R.;
RT   "Chemical punch packed in venoms makes centipedes excellent predators.";
RL   Mol. Cell. Proteomics 11:640-650(2012).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=24847043; DOI=10.1093/molbev/msu162;
RA   Undheim E.A., Jones A., Clauser K.R., Holland J.W., Pineda S.S., King G.F.,
RA   Fry B.G.;
RT   "Clawing through evolution: toxin diversification and convergence in the
RT   ancient lineage Chilopoda (centipedes).";
RL   Mol. Biol. Evol. 31:2124-2148(2014).
CC   -!- FUNCTION: Toxin that inhibits voltage-gated potassium channel currents
CC       in DRG neurons (IC(50)=about 570 nM). In vivo, induces neurotoxicity
CC       shown by twitching, paralysis, and body contraction. In vivo, insects
CC       injected with this toxin showed signs of neurotoxicity including
CC       twitching, paralysis, and body contraction.
CC       {ECO:0000269|PubMed:22595790}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22595790}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:22595790}.
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=3465.8; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:22595790};
CC   -!- TOXIC DOSE: the LD(50) ranges from 0.017 mg/kg in adult blowflies to
CC       13.0 mg/kg in cockroaches. {ECO:0000269|PubMed:22595790}.
CC   -!- SIMILARITY: Belongs to the scoloptoxin-07 family. {ECO:0000305}.
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DR   EMBL; JN646115; AFM55004.1; -; mRNA.
DR   AlphaFoldDB; I6RA66; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..41
FT                   /evidence="ECO:0000305|PubMed:22595790"
FT                   /id="PRO_0000425474"
FT   CHAIN           44..74
FT                   /note="Kappa-scoloptoxin(07)-Ssm2a"
FT                   /evidence="ECO:0000269|PubMed:22595790"
FT                   /id="PRO_0000425475"
FT   CONFLICT        66
FT                   /note="A -> V (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   74 AA;  8335 MW;  A0142C4136246E4D CRC64;
     MLVFYALLFV TVFSNTVMGA TIDKPIPKPI LREAIEEIEV NKRAQNHYCK EHNCPPGKHC
     PKVPIACVYG PCCF