ID   TX72C_SCOMU             Reviewed;          74 AA.
AC   I6R1R7;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 2.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Kappa-scoloptoxin(07)-Ssm2c {ECO:0000250|UniProtKB:I6RA66};
DE            Short=Kappa-SLPTX(07)-Ssm2c {ECO:0000250|UniProtKB:I6RA66};
DE   AltName: Full=Kappa-scoloptoxin-Ssm2c {ECO:0000303|PubMed:22595790};
DE            Short=Kappa-SLPTX-Ssm2c {ECO:0000303|PubMed:22595790};
DE   Flags: Precursor;
OS   Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra
OS   subspinipes mutilans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX   NCBI_TaxID=2836329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=22595790; DOI=10.1074/mcp.m112.018853;
RA   Yang S., Liu Z., Xiao Y., Li Y., Rong M., Liang S., Zhang Z., Yu H.,
RA   King G.F., Lai R.;
RT   "Chemical punch packed in venoms makes centipedes excellent predators.";
RL   Mol. Cell. Proteomics 11:640-650(2012).
CC   -!- FUNCTION: Inhibits voltage-gated potassium channels.
CC       {ECO:0000250|UniProtKB:I6RA66}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:22595790}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:22595790}.
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the scoloptoxin-07 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AFM55011.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; JQ757064; AFM55011.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; I6R1R7; -.
DR   SMR; I6R1R7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Signal; Toxin; Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..41
FT                   /evidence="ECO:0000250|UniProtKB:I6RA66"
FT                   /id="PRO_0000425477"
FT   CHAIN           44..74
FT                   /note="Kappa-scoloptoxin(07)-Ssm2c"
FT                   /evidence="ECO:0000250|UniProtKB:I6RA66"
FT                   /id="PRO_0000425478"
FT   CONFLICT        7
FT                   /note="P -> I (in Ref. 1; AFM55011)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        11..12
FT                   /note="SI -> IV (in Ref. 1; AFM55011)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   74 AA;  8266 MW;  C19DAAC867707117 CRC64;
     MLVFYAPLFV SIFSNTVMGA TIDKPIPKPI LREAIEKIAV NKRADSRYCK EEKCPPGKHC
     PKVPIVCVRG PCCF