C6G_CONRE
ID C6G_CONRE Reviewed; 26 AA.
AC P0DOZ3;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 1.
DT 02-JUN-2021, entry version 9.
DE RecName: Full=Conotoxin reg6(gamma) {ECO:0000303|PubMed:17153339};
OS Conus regius (Crown cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX NCBI_TaxID=101314;
RN [1]
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, GAMMA-CARBOXYGLUTAMATION AT GLU-4;
RP GLU-8; GLU-14; GLU-18; GLU-20 AND GLU-25, HYDROXYLATION AT PRO-5; PRO-10
RP AND PRO-15, AND TISSUE SPECIFICITY.
RC TISSUE=Venom;
RX PubMed=17153339; DOI=10.1007/978-3-540-30880-5_4;
RA Franco A., Pisarewicz K., Moller C., Mora D., Fields G.B., Mari F.;
RT "Hyperhydroxylation: a new strategy for neuronal targeting by venomous
RT marine molluscs.";
RL Prog. Mol. Subcell. Biol. 43:83-103(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17153339}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000269|PubMed:17153339}.
CC -!- MISCELLANEOUS: The mature peptide does not contain cysteine residues.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Gamma-carboxyglutamic acid; Hydroxylation;
KW Secreted.
FT PEPTIDE 1..26
FT /note="Conotoxin reg6(gamma)"
FT /evidence="ECO:0000269|PubMed:17153339"
FT /id="PRO_0000439370"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 4
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000269|PubMed:17153339"
FT MOD_RES 5
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:17153339"
FT MOD_RES 8
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000269|PubMed:17153339"
FT MOD_RES 10
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:17153339"
FT MOD_RES 14
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000269|PubMed:17153339"
FT MOD_RES 15
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:17153339"
FT MOD_RES 18
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000269|PubMed:17153339"
FT MOD_RES 20
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000269|PubMed:17153339"
FT MOD_RES 25
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000269|PubMed:17153339"
SQ SEQUENCE 26 AA; 2911 MW; EAC90EDA179079C4 CRC64;
RVLEPGXEDP DVGEPAGEYE HHLLEX
