ID   C6TF_LEPMJ              Reviewed;         521 AA.
AC   E5AE39;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Phomenoic acid biosynthesis cluster-specific transcriptional regulator {ECO:0000303|PubMed:23396262};
GN   Name=C6TF {ECO:0000303|PubMed:23396262}; ORFNames=LEMA_P002650;
OS   Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
OS   (Blackleg fungus) (Phoma lingam).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC   Leptosphaeria; Leptosphaeria maculans species complex.
OX   NCBI_TaxID=985895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8;
RX   PubMed=21326234; DOI=10.1038/ncomms1189;
RA   Rouxel T., Grandaubert J., Hane J.K., Hoede C., van de Wouw A.P.,
RA   Couloux A., Dominguez V., Anthouard V., Bally P., Bourras S.,
RA   Cozijnsen A.J., Ciuffetti L.M., Degrave A., Dilmaghani A., Duret L.,
RA   Fudal I., Goodwin S.B., Gout L., Glaser N., Linglin J., Kema G.H.J.,
RA   Lapalu N., Lawrence C.B., May K., Meyer M., Ollivier B., Poulain J.,
RA   Schoch C.L., Simon A., Spatafora J.W., Stachowiak A., Turgeon B.G.,
RA   Tyler B.M., Vincent D., Weissenbach J., Amselem J., Quesneville H.,
RA   Oliver R.P., Wincker P., Balesdent M.-H., Howlett B.J.;
RT   "Effector diversification within compartments of the Leptosphaeria maculans
RT   genome affected by Repeat-Induced Point mutations.";
RL   Nat. Commun. 2:202-202(2011).
RN   [2]
RP   IDENTIFICATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=23396262; DOI=10.1016/j.fgb.2013.01.008;
RA   Elliott C.E., Callahan D.L., Schwenk D., Nett M., Hoffmeister D.,
RA   Howlett B.J.;
RT   "A gene cluster responsible for biosynthesis of phomenoic acid in the plant
RT   pathogenic fungus, Leptosphaeria maculans.";
RL   Fungal Genet. Biol. 53:50-58(2013).
CC   -!- FUNCTION: Transcriptional regulator; part of the gene cluster that
CC       mediates the biosynthesis of phomenoic acid, a long chain aliphatic
CC       carboxylic acid that does not appear to be essential for pathogenicity
CC       but may play a role in allowing to outcompete other fungi in the
CC       environmental niche via its antifungal properties (PubMed:23396262).
CC       Positively regulates the expression of the cluster and subsequent
CC       production of phomenoic acid (PubMed:23396262).
CC       {ECO:0000269|PubMed:23396262}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:23396262}.
CC   -!- DISRUPTION PHENOTYPE: Leads to reduced expression of genes for the
CC       polyketide synthase PKS2, the cytochrome P450 monooxygenase P450, the
CC       alcohol dehydrogenase/quinone reductase YogA, the lipid transport
CC       exporter superfamily member RTA1 and the a major facilitator
CC       superfamily transporter MFS, as well as a marked reduction in phomenoic
CC       acid production. {ECO:0000269|PubMed:23396262}.
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DR   EMBL; FP929139; CBY01478.1; -; Genomic_DNA.
DR   RefSeq; XP_003844957.1; XM_003844909.1.
DR   AlphaFoldDB; E5AE39; -.
DR   EnsemblFungi; CBY01478; CBY01478; LEMA_P002650.1.
DR   GeneID; 13290519; -.
DR   eggNOG; ENOG502SM3X; Eukaryota.
DR   HOGENOM; CLU_021916_2_1_1; -.
DR   InParanoid; E5AE39; -.
DR   OMA; ETRWDAC; -.
DR   OrthoDB; 1303862at2759; -.
DR   Proteomes; UP000002668; Genome.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   InterPro; IPR021858; Fun_TF.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   Pfam; PF11951; Fungal_trans_2; 1.
PE   4: Predicted;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..521
FT                   /note="Phomenoic acid biosynthesis cluster-specific
FT                   transcriptional regulator"
FT                   /id="PRO_0000446536"
FT   DNA_BIND        46..76
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   521 AA;  58947 MW;  2FA2C09DE27C704F CRC64;
     MHMQFQLPGR RRRHRTTWIE WVLVHKSARS GGELKAVMED SDRKRHCWQC RRSCVVCDFT
     QPGCQRCSAA GVSCPGYSDI EPRKLKWLAP GKVLSRNHKA NKAHLVRKST TIATASAQAV
     EPKISDWNMR YNACILEDLT PIHELGRHPY IHHVSPERLK EAILVPEFLR SGLICMTLNH
     RMNRLGIRSN PGATDLVEKY YIHWGITIRS LSEQFNVENK RTSDVVIAGI LTILLGDIQN
     GAQVSWLHHL DGIHKLVSLR GGFRALAPSQ RLAPLLNCLW FIGIITNTTC PASYLNLSTI
     SHFEASDFMQ EHYSFASTPT QMFPPQLLAE VSKINYLRLQ AKSKKEYRDE HLSKDAYNIL
     ESIEAFSPEE SAQSKFSSKE DWMRIGTVYR SATALYCILS LQSVSVLPED SALRTRCVIH
     GQVLLRHLPE SLSSARTKRF MLWPLVLLGV EAVHSDMATR AFVSKQLPEL SRSVGTSIPL
     TAQSVLESFW ASGLKLWDAC FDRPYPFTMQ IAVDVSQVST P