ID   TX81A_CORWE             Reviewed;         206 AA.
AC   A0A023VZR2;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=U-scoloptoxin(08)-Cw1a {ECO:0000303|PubMed:24847043};
DE            Short=U-SLPTX(08)-Cw1a {ECO:0000303|PubMed:24847043};
DE   AltName: Full=U-SLPTX-Cw1a {ECO:0000303|PubMed:24602922};
DE   Flags: Precursor;
OS   Cormocephalus westwoodi (Westwood's green centipede).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Cormocephalus.
OX   NCBI_TaxID=1096223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 165-200, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=24602922; DOI=10.1016/j.jprot.2014.02.024;
RA   Undheim E.A., Sunagar K., Hamilton B.R., Jones A., Venter D.J., Fry B.G.,
RA   King G.F.;
RT   "Multifunctional warheads: diversification of the toxin arsenal of
RT   centipedes via novel multidomain transcripts.";
RL   J. Proteomics 102:1-10(2014).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=24847043; DOI=10.1093/molbev/msu162;
RA   Undheim E.A., Jones A., Clauser K.R., Holland J.W., Pineda S.S., King G.F.,
RA   Fry B.G.;
RT   "Clawing through evolution: toxin diversification and convergence in the
RT   ancient lineage Chilopoda (centipedes).";
RL   Mol. Biol. Evol. 31:2124-2148(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24602922}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24602922}.
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the scoloptoxin-08 family. {ECO:0000305}.
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DR   EMBL; KF130762; AHY22613.1; -; mRNA.
DR   AlphaFoldDB; A0A023VZR2; -.
DR   SMR; A0A023VZR2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Repeat; Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..164
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT                   /id="PRO_0000446727"
FT   CHAIN           165..206
FT                   /note="U-scoloptoxin(08)-Cw1a"
FT                   /evidence="ECO:0000269|PubMed:24602922"
FT                   /id="PRO_5001524781"
FT   REPEAT          37..43
FT                   /note="RLWRNWE 1; approximate"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          71..77
FT                   /note="RLWRNWE 2; approximate"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          104..110
FT                   /note="RLWRNWE 3; approximate"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          137..143
FT                   /note="RLWRNWE 4"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          164..170
FT                   /note="RLWRNWE 5; approximate"
FT                   /evidence="ECO:0000305|PubMed:24602922"
SQ   SEQUENCE   206 AA;  24947 MW;  3EADC39E469AB254 CRC64;
     MIFRVNLLFS CFCFVLFVFD FSNASKYDQG SLNIAKRLWR DWEREANAKD MERKEVKADA
     EGNAQMERER RLWRDWEASQ AKPLERRAWV EAVEASDQNE REKRLWRDWE GNQANDLERR
     AMEGLMEANE ENQRAKRLWR NWEANHEYEI ERKRDLPELK RRKRLWRNED QEVACTTKCS
     CSDNEIFSKV DHELTTSETK RVPCCC