ID   TX85A_SCOMO             Reviewed;         145 AA.
AC   A0A023W0W9;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 1.
DT   03-AUG-2022, entry version 9.
DE   RecName: Full=U-scoloptoxin-Sm5a {ECO:0000305};
DE            Short=U-SLPTX-Sm5a {ECO:0000305};
DE   AltName: Full=U-scoloptoxin-Er5-like {ECO:0000312|EMBL:AHY22619.1};
DE            Short=U-SLPTX-Er5-like {ECO:0000312|EMBL:AHY22619.1};
DE   Flags: Precursor;
OS   Scolopendra morsitans (Tanzanian blue ringleg centipede).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX   NCBI_TaxID=943129;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24602922; DOI=10.1016/j.jprot.2014.02.024;
RA   Undheim E.A., Sunagar K., Hamilton B.R., Jones A., Venter D.J., Fry B.G.,
RA   King G.F.;
RT   "Multifunctional warheads: diversification of the toxin arsenal of
RT   centipedes via novel multidomain transcripts.";
RL   J. Proteomics 102:1-10(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24602922}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24602922}.
CC   -!- SIMILARITY: Belongs to the scoloptoxin-08 family. {ECO:0000305}.
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DR   EMBL; KF130768; AHY22619.1; -; mRNA.
DR   AlphaFoldDB; A0A023W0W9; -.
DR   SMR; A0A023W0W9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Repeat; Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..111
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000446734"
FT   PEPTIDE         112..129
FT                   /note="U-scoloptoxin-Sm5a"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5001525379"
FT   PROPEP          130..145
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000446735"
FT   REPEAT          35..41
FT                   /note="RLWRNWE 1; approximate"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          51..57
FT                   /note="RLWRNWE 2"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          67..73
FT                   /note="RLWRNWE 3"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          81..87
FT                   /note="RLWRNWE 4"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          97..103
FT                   /note="RLWRNWE 5"
FT                   /evidence="ECO:0000305|PubMed:24602922"
SQ   SEQUENCE   145 AA;  18904 MW;  8B223F507E39B4AF CRC64;
     MSYTCMKGLL CFCLVLMFFE LTDGSDESQR QDMKRLWRHW EEEQQKDREK RLWRNWEDQE
     QKERERRLWR NWEDENQREK RLWRNWEDEE QVPRQKRLWR NWEESEQKEK RSFPEVKYEI
     EQNQELPQVK RKKRFWRDEE ESERS