ID   TX85B_ETHRU             Reviewed;         167 AA.
AC   A0A023W157;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=U-scoloptoxin(08)-Er5b {ECO:0000250|UniProtKB:A0A023W0B6};
DE            Short=U-SLPTX(08)-Er5b {ECO:0000250|UniProtKB:A0A023W0B6};
DE   Contains:
DE     RecName: Full=U-scoloptoxin-Er5.1a {ECO:0000303|PubMed:24602922};
DE              Short=U-SLPTX-Er5.1a {ECO:0000303|PubMed:24602922};
DE   Contains:
DE     RecName: Full=U-scoloptoxin-Er5.2a {ECO:0000303|PubMed:24602922};
DE              Short=U-SLPTX-Er5.2a {ECO:0000303|PubMed:24602922};
DE   Flags: Precursor;
OS   Ethmostigmus rubripes (Giant centipede).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Ethmostigmus.
OX   NCBI_TaxID=62613;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 95-111 AND 119-138,
RP   IDENTIFICATION BY MASS SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-95 AND
RP   GLN-119, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=24602922; DOI=10.1016/j.jprot.2014.02.024;
RA   Undheim E.A., Sunagar K., Hamilton B.R., Jones A., Venter D.J., Fry B.G.,
RA   King G.F.;
RT   "Multifunctional warheads: diversification of the toxin arsenal of
RT   centipedes via novel multidomain transcripts.";
RL   J. Proteomics 102:1-10(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24602922}. Note=The
CC       mature toxins are clearly liberated from the multidomain precursors in
CC       the venom gland prior to venom expulsion and not by venom proteases
CC       upon secretion. {ECO:0000269|PubMed:24602922}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24602922}.
CC   -!- SIMILARITY: Belongs to the scoloptoxin-08 family. {ECO:0000305}.
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DR   EMBL; KF130754; AHY22605.1; -; mRNA.
DR   AlphaFoldDB; A0A023W157; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Pyrrolidone carboxylic acid; Repeat; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..94
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT                   /id="PRO_0000446736"
FT   PEPTIDE         95..111
FT                   /note="U-scoloptoxin-Er5.1a"
FT                   /evidence="ECO:0000269|PubMed:24602922"
FT                   /id="PRO_5001526954"
FT   PROPEP          112..118
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT                   /id="PRO_0000446737"
FT   PEPTIDE         119..138
FT                   /note="U-scoloptoxin-Er5.2a"
FT                   /evidence="ECO:0000269|PubMed:24602922"
FT                   /id="PRO_0000446738"
FT   PROPEP          139..167
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT                   /id="PRO_0000446739"
FT   REPEAT          34..40
FT                   /note="RLWRNWE 1"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          61..67
FT                   /note="RLWRNWE 2"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          86..92
FT                   /note="RLWRNWE 3"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          107..113
FT                   /note="RLWRNWE 4; approximate"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          134..140
FT                   /note="RLWRNWE 5"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REGION          147..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         95
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:24602922"
FT   MOD_RES         119
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:24602922"
SQ   SEQUENCE   167 AA;  20708 MW;  273B9C85E32EE4EB CRC64;
     MKTNCEFPLL CLLIVLVANV EGEVEDTGLK MVKRLWRNWE DPEQRQLLDQ ETELEKQREK
     RLWRNWEDLE LRQLLNEFAE NQREKRLWRN WERRQVANED DGEKAKELWR NWEDLKRRQV
     ADLNDEQETQ RDKRLWRNWE DNHATLRKRS ADSLSRQKRL GKERGKE