TX85C_ETHRU
ID TX85C_ETHRU Reviewed; 167 AA.
AC A0A023W0V9;
DT 10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT 09-JUL-2014, sequence version 1.
DT 25-MAY-2022, entry version 10.
DE RecName: Full=U-scoloptoxin-Er5c {ECO:0000305};
DE Short=U-SLPTX-Er5c {ECO:0000305};
DE AltName: Full=U-scoloptoxin-Er5-like {ECO:0000312|EMBL:AHY22609.1};
DE Short=U-SLPTX-Er5-like {ECO:0000312|EMBL:AHY22609.1};
DE Contains:
DE RecName: Full=U-scoloptoxin-Er5.1b {ECO:0000250|UniProtKB:A0A023W0B6};
DE Short=U-SLPTX-Er5.1b {ECO:0000250|UniProtKB:A0A023W0B6};
DE Contains:
DE RecName: Full=U-scoloptoxin-Er5.2b {ECO:0000250|UniProtKB:A0A023W0B6};
DE Short=U-SLPTX-Er5.2b {ECO:0000250|UniProtKB:A0A023W0B6};
DE Flags: Precursor;
OS Ethmostigmus rubripes (Giant centipede).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Scolopendromorpha; Scolopendridae; Ethmostigmus.
OX NCBI_TaxID=62613;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=24602922; DOI=10.1016/j.jprot.2014.02.024;
RA Undheim E.A., Sunagar K., Hamilton B.R., Jones A., Venter D.J., Fry B.G.,
RA King G.F.;
RT "Multifunctional warheads: diversification of the toxin arsenal of
RT centipedes via novel multidomain transcripts.";
RL J. Proteomics 102:1-10(2014).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24602922}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:24602922}.
CC -!- SIMILARITY: Belongs to the scoloptoxin-08 family. {ECO:0000305}.
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DR EMBL; KF130758; AHY22609.1; -; mRNA.
DR AlphaFoldDB; A0A023W0V9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Pyrrolidone carboxylic acid; Repeat;
KW Secreted; Signal; Toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..94
FT /evidence="ECO:0000305|PubMed:24602922"
FT /id="PRO_0000446740"
FT PEPTIDE 95..111
FT /note="U-scoloptoxin-Er5.1b"
FT /evidence="ECO:0000250|UniProtKB:A0A023W0B6"
FT /id="PRO_5001524647"
FT PROPEP 112..118
FT /evidence="ECO:0000305|PubMed:24602922"
FT /id="PRO_0000446741"
FT PEPTIDE 119..138
FT /note="U-scoloptoxin-Er5.2b"
FT /evidence="ECO:0000250|UniProtKB:A0A023W0B6"
FT /id="PRO_0000446742"
FT PROPEP 139..167
FT /evidence="ECO:0000250|UniProtKB:A0A023W0B6"
FT /id="PRO_0000446743"
FT REPEAT 34..40
FT /note="RLWRNWE 1"
FT /evidence="ECO:0000305|PubMed:24602922"
FT REPEAT 61..67
FT /note="RLWRNWE 2"
FT /evidence="ECO:0000305|PubMed:24602922"
FT REPEAT 86..92
FT /note="RLWRNWE 3"
FT /evidence="ECO:0000305|PubMed:24602922"
FT REPEAT 107..113
FT /note="RLWRNWE 4; approximate"
FT /evidence="ECO:0000305|PubMed:24602922"
FT REPEAT 134..140
FT /note="RLWRNWE 5"
FT /evidence="ECO:0000305|PubMed:24602922"
FT REGION 147..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 95
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:A0A023W0B6"
FT MOD_RES 119
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:A0A023W0B6"
SQ SEQUENCE 167 AA; 20745 MW; 35AAA81C92EDAD1C CRC64;
MKTNCEFPLL CLLIVLVANV EGEVEDTGLK MVKRLWRNWE DPEQRQLLDQ EAEQEKQLEK
RLWRNWEDLE LRQLLNEFAE NQREKRLWRN WERRQVAKED DGEKPKELWR NWEDLKRRQV
VDLNDEQKTQ RDKRLWRNWE DNHATLRKRS ADSLSRQKRL GRERGKE
