ID   TX85E_ETHRU             Reviewed;         131 AA.
AC   A0A023W163;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=U-scoloptoxin-Er5e {ECO:0000305};
DE            Short=U-SLPTX-Er5e {ECO:0000305};
DE   AltName: Full=U-scoloptoxin-Er5-like {ECO:0000312|EMBL:AHY22610.1};
DE            Short=U-SLPTX-Er5-like;
DE   AltName: Full=U-scoloptoxin-Er5.1c {ECO:0000250|UniProtKB:A0A023W0B6};
DE            Short=U-SLPTX-Er5.1c {ECO:0000250|UniProtKB:A0A023W0B6};
DE   Flags: Precursor;
OS   Ethmostigmus rubripes (Giant centipede).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Ethmostigmus.
OX   NCBI_TaxID=62613;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24602922; DOI=10.1016/j.jprot.2014.02.024;
RA   Undheim E.A., Sunagar K., Hamilton B.R., Jones A., Venter D.J., Fry B.G.,
RA   King G.F.;
RT   "Multifunctional warheads: diversification of the toxin arsenal of
RT   centipedes via novel multidomain transcripts.";
RL   J. Proteomics 102:1-10(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24602922}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24602922}.
CC   -!- SIMILARITY: Belongs to the scoloptoxin-08 family. {ECO:0000305}.
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DR   EMBL; KF130759; AHY22610.1; -; mRNA.
DR   AlphaFoldDB; A0A023W163; -.
DR   SMR; A0A023W163; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Pyrrolidone carboxylic acid; Repeat;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..94
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT                   /id="PRO_0000446746"
FT   PEPTIDE         95..111
FT                   /note="U-scoloptoxin-Er5e"
FT                   /evidence="ECO:0000250|UniProtKB:A0A023W0B6"
FT                   /id="PRO_5001524793"
FT   PROPEP          112..131
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT                   /id="PRO_0000446747"
FT   REPEAT          34..40
FT                   /note="RLWRNWE 1"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          61..67
FT                   /note="RLWRNWE 2"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          86..92
FT                   /note="RLWRNWE 3"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   REPEAT          107..113
FT                   /note="RLWRNWE 4; approximate"
FT                   /evidence="ECO:0000305|PubMed:24602922"
FT   MOD_RES         95
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:A0A023W0B6"
SQ   SEQUENCE   131 AA;  16301 MW;  8FBEAFBB4924F4BE CRC64;
     MKTNCEFPLL CLLIVLVANV EGEVEDNELK MVKRLWRNWE DPEQRQLLDQ EAEQEKQREK
     RLWRNWEDLE LRQLLNEFAE NQREKRLWRN WERRQVANED DGEKPKELWR NWEDLKRRQV
     VDLNDEQKTT G