ID   TX90D_PHONI             Reviewed;         100 AA.
AC   P0C2S8;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=U12-ctenitoxin-Pn1a;
DE            Short=U12-CNTX-Pn1a;
DE   AltName: Full=Neurotoxin Pn3-6B;
DE   Flags: Precursor;
OS   Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Phoneutria.
OX   NCBI_TaxID=6918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=12782075; DOI=10.1016/s0041-0101(03)00011-4;
RA   Cardoso F.C., Pacifico L.G., Carvalho D.C., Victoria J.M.N., Neves A.L.G.,
RA   Chavez-Olortegui C., Gomez M.V., Kalapothakis E.;
RT   "Molecular cloning and characterization of Phoneutria nigriventer toxins
RT   active on calcium channels.";
RL   Toxicon 41:755-763(2003).
CC   -!- FUNCTION: Probable neurotoxin.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 09 (Tx3-6) family. {ECO:0000305}.
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DR   AlphaFoldDB; P0C2S8; -.
DR   ArachnoServer; AS000267; U12-ctenitoxin-Pn1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   PROPEP          29..41
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000284876"
FT   CHAIN           43..100
FT                   /note="U12-ctenitoxin-Pn1a"
FT                   /id="PRO_0000284877"
FT   DISULFID        44..58
FT                   /evidence="ECO:0000305"
FT   DISULFID        51..64
FT                   /evidence="ECO:0000305"
FT   DISULFID        57..82
FT                   /evidence="ECO:0000305"
FT   DISULFID        66..80
FT                   /evidence="ECO:0000305"
FT   DISULFID        90..97
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   100 AA;  11305 MW;  A109748FE94848FB CRC64;
     MKYRIFKMKY TLLFLSVIAL VHIFAVEAKD EPESDALVPQ ERGCLDIGKT CKDDCECCGC
     GNVCYCPFDW FGGKWQPFGC SCAYGLKYVC AHKQKKCPNV