TXA1_ANDAU
ID TXA1_ANDAU Reviewed; 80 AA.
AC Q4LCT3;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Toxin-like peptide AaF1CA1;
DE Flags: Precursor;
OS Androctonus australis (Sahara scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Androctonus.
OX NCBI_TaxID=6858;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAH03782.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Venom gland {ECO:0000269|PubMed:15963953};
RX PubMed=15963953; DOI=10.1016/j.bbrc.2005.05.148;
RA Martin-Eauclaire M.-F., Ceard B., Bosmans F., Rosso J.-P., Tytgat J.,
RA Bougis P.E.;
RT "New 'birtoxin analogs' from Androctonus australis venom.";
RL Biochem. Biophys. Res. Commun. 333:524-530(2005).
CC -!- FUNCTION: Probable neurotoxin that inhibits ion channels.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01493}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000269|PubMed:15963953}.
CC -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the long (3 C-C) scorpion toxin superfamily.
CC {ECO:0000305}.
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DR EMBL; AJ781829; CAH03782.1; -; mRNA.
DR AlphaFoldDB; Q4LCT3; -.
DR SMR; Q4LCT3; -.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0008200; F:ion channel inhibitor activity; ISS:UniProtKB.
DR GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.30.10; -; 1.
DR InterPro; IPR044062; LCN-type_CS_alpha_beta_dom.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR InterPro; IPR002061; Scorpion_toxinL/defensin.
DR Pfam; PF00537; Toxin_3; 1.
DR SUPFAM; SSF57095; SSF57095; 1.
DR PROSITE; PS51863; LCN_CSAB; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Signal;
KW Toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255, ECO:0000312|EMBL:CAH03782.1"
FT CHAIN 23..80
FT /note="Toxin-like peptide AaF1CA1"
FT /evidence="ECO:0000312|EMBL:CAH03782.1"
FT /id="PRO_0000228816"
FT DOMAIN 25..80
FT /note="LCN-type CS-alpha/beta"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT DISULFID 40..63
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT DISULFID 49..68
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT DISULFID 53..70
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
SQ SEQUENCE 80 AA; 9351 MW; 379934711853264C CRC64;
MMKLVLFSVI VILFSLIGSI HGADVPGNYP LRPFRYRYGC AVPGDSDYCV RVCRKHGVRY
GYCWFFTCWC EYLEDKNIKI