TXA2_LATGE
ID TXA2_LATGE Reviewed; 88 AA.
AC V9QFG7; V9QFH1;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 1.
DT 25-MAY-2022, entry version 12.
DE RecName: Full=Alpha-latrotoxin associated low molecular weight protein 2 {ECO:0000303|PubMed:24316130};
DE Short=Alpha-latrotoxin-associated LMWP2 {ECO:0000303|PubMed:24316130};
DE AltName: Full=Latrodectin-2 {ECO:0000303|PubMed:24316130};
DE Flags: Precursor;
OS Latrodectus geometricus (Brown widow spider).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Araneoidea; Theridiidae; Latrodectus.
OX NCBI_TaxID=156851;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Venom gland;
RX PubMed=24316130; DOI=10.1016/j.gene.2013.11.054;
RA McCowan C., Garb J.E.;
RT "Recruitment and diversification of an ecdysozoan family of neuropeptide
RT hormones for black widow spider venom expression.";
RL Gene 536:366-375(2014).
CC -!- FUNCTION: May increase the toxicity of alpha-latrotoxin and/or other
CC venom components. Is non-toxic to mice and to the cockroach Periplaneta
CC americana. {ECO:0000250|UniProtKB:Q4U4N3}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q4U4N3}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:24316130}.
CC -!- MISCELLANEOUS: Co-purifies with latroinsectotoxin.
CC {ECO:0000250|UniProtKB:Q4U4N3}.
CC -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC {ECO:0000305|PubMed:24316130}.
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DR EMBL; KF751515; AHC13260.1; -; mRNA.
DR EMBL; KF751525; AHC13270.1; -; Genomic_DNA.
DR AlphaFoldDB; V9QFG7; -.
DR SMR; V9QFG7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.2010.10; -; 1.
DR InterPro; IPR031098; Crust_neurohorm.
DR InterPro; IPR035957; Crust_neurohorm_sf.
DR Pfam; PF01147; Crust_neurohorm; 1.
DR SUPFAM; SSF81778; SSF81778; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..88
FT /note="Alpha-latrotoxin associated low molecular weight
FT protein 2"
FT /evidence="ECO:0000250|UniProtKB:V9QEI7"
FT /id="PRO_0000432881"
FT DISULFID 30..66
FT /evidence="ECO:0000250|UniProtKB:P55847"
FT DISULFID 46..62
FT /evidence="ECO:0000250|UniProtKB:P55847"
FT DISULFID 49..75
FT /evidence="ECO:0000250|UniProtKB:P55847"
FT CONFLICT 70
FT /note="E -> Q (in Ref. 1; AHC13270)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 88 AA; 9970 MW; AF578CCEDBA8E30D CRC64;
MLKLICIVFL VTVLTFVVGE DTLDPAEYGC PSDVDMAELT EKNEVCLRCE DFHKEGVAFT
LCKTNCFTTE YYKNCVKDLE EAGKETEE