ID   TXA2_LATHE              Reviewed;          88 AA.
AC   V9QEI7; V9QES2; V9QFG5;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Alpha-latrotoxin associated low molecular weight protein 2 {ECO:0000250|UniProtKB:Q4U4N3};
DE            Short=Alpha-latrotoxin-associated LMWP2 {ECO:0000250|UniProtKB:Q4U4N3};
DE   AltName: Full=Latrodectin-2 {ECO:0000303|PubMed:24316130};
DE   Flags: Precursor;
OS   Latrodectus hesperus (Western black widow spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Araneoidea; Theridiidae; Latrodectus.
OX   NCBI_TaxID=256737;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24316130; DOI=10.1016/j.gene.2013.11.054;
RA   McCowan C., Garb J.E.;
RT   "Recruitment and diversification of an ecdysozoan family of neuropeptide
RT   hormones for black widow spider venom expression.";
RL   Gene 536:366-375(2014).
CC   -!- FUNCTION: May increase the toxicity of alpha-latrotoxin and/or other
CC       venom components. Is non-toxic to mice and to the cockroach Periplaneta
CC       americana. {ECO:0000250|UniProtKB:Q4U4N3}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q4U4N3}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Co-purifies with latroinsectotoxin.
CC       {ECO:0000250|UniProtKB:Q4U4N3}.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305|PubMed:24316130}.
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DR   EMBL; KF751509; AHC13254.1; -; mRNA.
DR   EMBL; KF751510; AHC13255.1; -; mRNA.
DR   EMBL; KF751511; AHC13256.1; -; mRNA.
DR   EMBL; KF751526; AHC13271.1; -; Genomic_DNA.
DR   AlphaFoldDB; V9QEI7; -.
DR   SMR; V9QEI7; -.
DR   PRIDE; V9QEI7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..88
FT                   /note="Alpha-latrotoxin associated low molecular weight
FT                   protein 2"
FT                   /id="PRO_0000432880"
FT   DISULFID        30..66
FT                   /evidence="ECO:0000250|UniProtKB:P55847"
FT   DISULFID        46..62
FT                   /evidence="ECO:0000250|UniProtKB:P55847"
FT   DISULFID        49..75
FT                   /evidence="ECO:0000250|UniProtKB:P55847"
FT   CONFLICT        38
FT                   /note="D -> E (in Ref. 1; AHC13255/AHC13256)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        72
FT                   /note="F -> P (in Ref. 1; AHC13271)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   88 AA;  9863 MW;  904B4FE655987130 CRC64;
     MLKLICIAFL VTVLTLVAGE DSLDPAEYGC ADDINQEDLL KKNDVCLQCE DLHKEGVVFS
     LCKTNCFTTQ YFTNCVKDLE EAEKEPPE