ID   TXA2_LATTR              Reviewed;          88 AA.
AC   Q4U4N3; Q9TWG5;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Alpha-latrotoxin-associated low molecular weight protein-2 {ECO:0000303|PubMed:7570633};
DE            Short=Alpha-latrotoxin-associated LMWP2 {ECO:0000303|PubMed:7570633};
DE   AltName: Full=Latrodectin-2 {ECO:0000250|UniProtKB:V9QEI7};
DE   Flags: Precursor;
OS   Latrodectus tredecimguttatus (Mediterranean black widow spider)
OS   (Latrodectus mactans tredecimguttatus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Araneoidea; Theridiidae; Latrodectus.
OX   NCBI_TaxID=6925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lipkin A.V., Pluzhnikov K.A., Grishin E.V.;
RT   "Low molecular weight components from black widow spider venom.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 64-82, PYROGLUTAMATE FORMATION AT GLN-20, FUNCTION,
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Venom;
RX   PubMed=7570633; DOI=10.1016/0041-0101(94)00166-6;
RA   Volkova T.M., Pluzhnikov K.A., Woll P.G., Grishin E.V.;
RT   "Low molecular weight components from black widow spider venom.";
RL   Toxicon 33:483-489(1995).
CC   -!- FUNCTION: May increase the toxicity of alpha-latrotoxin and/or other
CC       venom components. Is non-toxic to mice and to the cockroach Periplaneta
CC       americana. {ECO:0000269|PubMed:7570633}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7570633}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:7570633}.
CC   -!- PTM: The N-terminus is blocked. {ECO:0000269|PubMed:7570633}.
CC   -!- MISCELLANEOUS: Co-purifies with latroinsectotoxin.
CC       {ECO:0000269|PubMed:7570633}.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   EMBL; DQ011856; AAY33774.1; -; mRNA.
DR   AlphaFoldDB; Q4U4N3; -.
DR   SMR; Q4U4N3; -.
DR   ArachnoServer; AS000720; alpha-Latrotoxin-associated LMWP2.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Pyrrolidone carboxylic acid;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..88
FT                   /note="Alpha-latrotoxin-associated low molecular weight
FT                   protein-2"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000388749"
FT   MOD_RES         20
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000305|PubMed:7570633"
FT   DISULFID        30..66
FT                   /evidence="ECO:0000250|UniProtKB:P55847"
FT   DISULFID        46..62
FT                   /evidence="ECO:0000250|UniProtKB:P55847"
FT   DISULFID        49..75
FT                   /evidence="ECO:0000250|UniProtKB:P55847"
FT   CONFLICT        66
FT                   /note="C -> P (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        75..77
FT                   /note="CVK -> PVW (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        82
FT                   /note="A -> R (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   88 AA;  9838 MW;  77EDFBE47FF1D777 CRC64;
     MLKLICIAFL VTVLTLVAGQ DSLDPAEFGC ADDVNQAELL KNNDICLQCE DLHKEGVVFS
     LCKTNCFTTE YFQHCVKDLE EAKKEPPE